Evidence map›Paper›PMID 31186335›Full record

ArticlemSystems2019

Synthetic Gene Circuits Enable Systems-Level Biosensor Trigger Discovery at the Host-Microbe Interface.

Alexander D Naydich, Shannon N Nangle, Johannes J Bues, Disha Trivedi, Nabeel Nissar, Mara C Inniss, Matthew J Niederhuber, Jeffrey C Way, Pamela A Silver, David T Riglar

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 51 citations in OpenAlex.

  1. Living Microbial Drugs.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  2. Review
  3. Bacteria as living biosensors for DNA.Nature reviews bioengineering · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Emergent evolutionary forces in spatial models of luminal growth and their application to the human gut microbiota.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  11. Next-Generation Probiotics for Inflammatory Bowel Disease.International journal of molecular sciences · 2022
    Review
  12. Review
  13. Review
  14. Review
  15. Journal of biological methods · 2021
    Article
  16. Human Microbiome and Its Medical Applications.Frontiers in molecular biosciences · 2021
    Review
  17. Review
  18. Article
  19. Biosensing in Smart Engineered Probiotics.Biotechnology journal · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Alexander D NaydichDepartment of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA.
Shannon N NangleDepartment of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA.
Johannes J BuesDepartment of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA.
Disha TrivediDepartment of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA.
Nabeel NissarDepartment of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA.
Mara C InnissDepartment of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA.
Matthew J NiederhuberDepartment of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA.
Jeffrey C WayWyss Institute for Biologically Inspired Engineering, Boston, Massachusetts, USA.
Pamela A SilverDepartment of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA Pamela_Silver@hms.harvard.edu d.riglar@imperial.ac.uk.
David T RiglarDepartment of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA Pamela_Silver@hms.harvard.edu d.riglar@imperial.ac.uk.ORCID https://orcid.org/0000-0002-5004-4373
Harvard University · US

Funding

Quantification of genetic circuits for detection of intestinal inflammationF32DK112640 · NIDDK · HARVARD UNIVERSITY · PI NANGLE, SHANNON · 2017 to 2019
$166k
NIDDK NIH HHS F32 DK112640
6 · The paper itself

Abstract

Engineering synthetic circuits into intestinal bacteria to sense, record, and respond to

Indexed as

biosensorssynthetic biology

Identifiers

PMID31186335
PMCPMC6561318
OpenAlexW2952756481

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.