Evidence map›Paper›PMID 31186331›Full record

ArticlemBio2019

Extensive Epitranscriptomic Methylation of A and C Residues on Murine Leukemia Virus Transcripts Enhances Viral Gene Expression.

David G Courtney, Andrea Chalem, Hal P Bogerd, Brittany A Law, Edward M Kennedy, Christopher L Holley, Bryan R Cullen

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 75 citations in OpenAlex.

  1. Article
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  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Epitranscriptomic mScience advances · 2024
    Article
  14. Article
  15. Article
  16. Dynamic changes in RNA mCellular and molecular life sciences : CMLS · 2024
    Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

  • Commented on by
    m2019
5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

David G CourtneyDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.
Andrea ChalemDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.
Hal P BogerdDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.
Brittany A LawDepartment of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Edward M KennedyDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.
Christopher L HolleyDepartment of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Bryan R CullenDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA bryan.cullen@duke.edu.
Duke Medical Center · USDuke University · USDuke University Hospital · US

Funding

Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI DONNA NIEDZWIECKI · 1985 to 2026
$174.8M
The Center for HIV RNA Studies (CRNA)U54AI150470 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TELESNITSKY, ALICE · 2019 to 2021
$15.1M
The Center for HIV RNA Studies (CRNA)U54GM103297 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TELESNITSKY, ALICE · 2017 to 2018
$10.2M
MULTIDISCIPLINARY HEART &VASCULAR DISEASEST32HL007101 · NHLBI · DUKE UNIVERSITY · PI FREEDMAN, NEIL J. · 1985 to 2020
$9.8M
Epitranscriptomic modification of HIV-1 transcripts: Effects of drugs of abuseR01DA046111 · NIDA · DUKE UNIVERSITY · PI CULLEN, BRYAN R. · 2018 to 2022
$1.6M
Effect of m6A methylation of HIV-1 transcripts on viral replicationR56AI124973 · NIAID · DUKE UNIVERSITY · PI CULLEN, BRYAN R. · 2017 to 2017
$398k
NCI NIH HHS P30 CA014236NHLBI NIH HHS T32 HL007101NIAID NIH HHS R56 AI124973NIAID NIH HHS U54 AI150470NIDA NIH HHS R01 DA046111NIGMS NIH HHS U54 GM103297
6 · The paper itself

Abstract

While it has been known for several years that viral RNAs are subject to the addition of several distinct covalent modifications to individual nucleotides, collectively referred to as epitranscriptomic modifications, the effect of these editing events on viral gene expression has been controversial. Here, we report the purification of murine leukemia virus (MLV) genomic RNA to homogeneity and show that this viral RNA contains levels of

Indexed as

DNA MethylationVirus ReplicationAdenosineCytosineGene ExpressionGenome, ViralLeukemia Virus, MurineMethyltransferasesRNA, MessengerRNA, ViralAdenosineCytosineMethyltransferasesRNA, MessengerRNA, Viralepitranscriptomicmurine leukemia virusposttranscriptional gene regulationretrovirusRNA editing

Identifiers

PMID31186331
PMCPMC6561033
OpenAlexW2953093977

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.