Evidence map›Paper›PMID 31186328›Full record

ArticlemBio2019

The Landscape of Phenotypic and Transcriptional Responses to Ciprofloxacin in Acinetobacter baumannii: Acquired Resistance Alleles Modulate Drug-Induced SOS Response and Prophage Replication.

Edward Geisinger, Germán Vargas-Cuebas, Nadav J Mortman, Sapna Syal, Yunfei Dai, Elizabeth L Wainwright, David Lazinski, Stephen Wood, Zeyu Zhu, Jon Anthony and 2 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 46 citations in OpenAlex.

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  6. Large-scale combination screens reveal small-molecule sensitization of antibiotic-resistant gram-negative ESKAPE pathogens.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  8. Fundamental research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Edward GeisingerDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Germán Vargas-CuebasDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Nadav J MortmanDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Sapna SyalDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Yunfei DaiDepartment of Biology, Northeastern University, Boston, Massachusetts, USA.
Elizabeth L WainwrightDepartment of Biology, Northeastern University, Boston, Massachusetts, USA.
David LazinskiDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Stephen WoodDepartment of Biology, Boston College, Chestnut Hill, Massachusetts, USA.
Zeyu ZhuDepartment of Biology, Boston College, Chestnut Hill, Massachusetts, USA.
Jon AnthonyDepartment of Biology, Boston College, Chestnut Hill, Massachusetts, USA.
Tim van OpijnenDepartment of Biology, Boston College, Chestnut Hill, Massachusetts, USA.
Ralph R IsbergDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA ralph.isberg@tufts.edu.
Tufts University · USBoston College · USNortheastern University · US

Funding

Predicting the emergence of antibiotic resistance through multi-omics approaches and Immune System-surveillanU01AI124302 · NIAID · BOSTON COLLEGE · PI BENTO, JOSE, COOPER, VAUGHN · 2016 to 2020
$10.2M
Tufts Post-Baccalaureate Research Education ProgramR25GM066567 · NIGMS · TUFTS UNIVERSITY BOSTON · PI RIOS, MARIBEL · 2002 to 2024
$5.7M
Identification of the Achilles’ heel in Acinetobacter fluoroquinolone-resistant mutantsR21AI128328 · NIAID · TUFTS UNIVERSITY BOSTON · PI ISBERG, RALPH R. · 2017 to 2018
$454k
Type VI Protein Secretion in an Emerging Multidrug-Resistant PathogenF32AI098358 · NIAID · TUFTS UNIVERSITY BOSTON · PI GEISINGER, EDWARD · 2012 to 2014
$168k
NIAID NIH HHS F32 AI098358NIAID NIH HHS R21 AI128328NIAID NIH HHS U01 AI124302NIGMS NIH HHS R25 GM066567
6 · The paper itself

Abstract

The emergence of fluoroquinolone resistance in nosocomial pathogens has restricted the clinical efficacy of this antibiotic class. In

Indexed as

SOS Response, GeneticsAcinetobacter baumanniiAllelesAnti-Bacterial AgentsCiprofloxacinDNA DamageDNA GyraseDNA Topoisomerase IVDrug Resistance, BacterialGene Expression ProfilingMicrobial Sensitivity TestsMutationPhenotypeProphagesVirus ReplicationWhole Genome SequencingAnti-Bacterial AgentsCiprofloxacinDNA GyraseDNA Topoisomerase IVAcinetobacterantibiotic resistanceciprofloxacinDNA gyrasefitnessfluoroquinoloneprophagetopoisomerase IV

Identifiers

PMID31186328
PMCPMC6561030
OpenAlexW2950607490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.