Evidence map›Paper›PMID 31186319›Full record

ArticlemBio2019

Genomic Identification of the TOR Signaling Pathway as a Target of the Plant Alkaloid Antofine in the Phytopathogen Fusarium graminearum.

Christopher Mogg, Christopher Bonner, Li Wang, Johann Schernthaner, Myron Smith, Darrell Desveaux, Rajagopal Subramaniam

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. An ABC-B Transporter Helps ProtectJournal of fungi (Basel, Switzerland) · 2026
    Article
  2. Review
  3. Epistatic Relationship betweenJournal of fungi (Basel, Switzerland) · 2023
    Article
  4. Review
  5. Article
  6. Antofine Triggers the Resistance AgainstFrontiers in microbiology · 2022
    Article
  7. Nicotinamide Effectively Suppresses Fusarium Head Blight in Wheat Plants.International journal of molecular sciences · 2021
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Christopher Mogg *Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada.
Christopher Bonner *Agriculture and Agri-Food Canada, Ottawa, Ontario, Canada.
Li WangAgriculture and Agri-Food Canada, Ottawa, Ontario, Canada.
Johann SchernthanerAgriculture and Agri-Food Canada, Ottawa, Ontario, Canada.
Myron SmithDepartment of Biology, Carleton University, Ottawa, Ontario, Canada.
Darrell DesveauxDepartment of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada Darrell.desveaux@utoronto.ca subramaniamra@agr.gc.ca.
Rajagopal SubramaniamAgriculture and Agri-Food Canada, Ottawa, Ontario, Canada Darrell.desveaux@utoronto.ca subramaniamra@agr.gc.ca.
Agriculture and Agri-Food Canada · CAUniversity of Toronto · CACarleton University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antofine, a phenanthroindolizidine alkaloid, is a bioactive natural product isolated from milkweeds that exhibits numerous biological activities, including anticancer, antimicrobial, antiviral, and anti-inflammatory properties. However, the direct targets and mode of action of antofine have not been determined. In this report, we show that antofine displays antifungal properties against the phytopathogen

Indexed as

Signal TransductionFungicides, IndustrialFusariumGenomicsIndolesPhenanthrolinesPlant DiseasesTOR Serine-Threonine KinasesTriticumVirulenceantofineFungicides, IndustrialIndolesPhenanthrolinesTOR Serine-Threonine Kinasesdrug targetsFusariumrapamycin

Identifiers

PMID31186319
PMCPMC6561021
OpenAlexW2949349466

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.