SynthesisCritical care (London, England)2019
Aetiology and outcomes of sepsis in adults in sub-Saharan Africa: a systematic review and meta-analysis.
Synthesis in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pooled it
- Systematic review and bibliometric analysis of African anesthesia and critical care medicine research part II: a scientometric analysis of the 116 most cited articles.BMC anesthesiology · 2021Pooled it
- Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis.Intensive care medicine · 2020Pooled it
- Recommendations for fluid management of adults with sepsis in sub-Saharan Africa: a systematic review of guidelines.Critical care (London, England) · 2020Pooled it
- Immediate or high-dose antituberculosis therapy for HIV-related sepsis in Tanzania and Uganda (ATLAS): a phase 3, open-label, randomised, controlled, 2 × 2 factorial, superiority trial.The Lancet. Infectious diseases · 2026Trial
- Proteomic Immune Signatures of Severe HIV-Associated Tuberculosis in Sub-Saharan Africa: A Prospective, Multicenter Analysis From Uganda.Critical care explorations · 2026Observational
- Approximating Molecular Sepsis Subtypes Using Bedside Data in Resource-Limited Settings: A Multicenter Analysis From Uganda.Critical care explorations · 2026Observational
- The Impact of Malnutrition on Host Responses to Severe Infection in Adults: A Multicenter Analysis from Uganda.medRxiv : the preprint server for health sciences · 2026Article
- Assessment of Bedside-Adaptable Models to Predict Molecular Sepsis Subtypes in a Resource-Limited Setting: A Multicenter Analysis from Uganda.medRxiv : the preprint server for health sciences · 2026Article
- Article
- Patterns and predictors of readmission among sepsis survivors in a tertiary emergency department in Ethiopia.IJID regions · 2026Article
- Real-world longitudinal validation of high-income-country-derived sepsis endotypes in sub-Saharan Africa: a nested prospective multicenter study.Critical care (London, England) · 2026Article
- Treatment outcomes among patients with mycobacterial blood stream infection in a tertiary hospital:a retrospective study form 2019 to 2023.Journal of clinical tuberculosis and other mycobacterial diseases · 2026Article
- Aetiology of sepsis in adults living with HIV in East Africa: a secondary analysis of an open-label, multicentre, randomised, controlled phase 3 trial.EClinicalMedicine · 2026Article
- Ensuring effective transitions in care for hospitalized people living with HIV.Frontiers in public health · 2026Review
- Prognostic value of low-cost white blood cell indices and procalcitonin for mortality in Rwandan sepsis patients: a prospective intensive care unit study.Tropical medicine and health · 2025Article
- Aging and Host Responses to Severe Infection: Proteomic Analysis of a Prospective Multicenter Cohort From Uganda.Critical care explorations · 2025Article
- Mpox, HIV, and a Compounding Sepsis Crisis in Africa.The American journal of tropical medicine and hygiene · 2025Article
- Identification of transcriptomic sepsis endotypes in sub-Saharan Africa: derivation, validation, and global alignment in two Ugandan cohorts.Intensive care medicine · 2025Observational
- Applying the three delays qualitative model to sepsis care seeking and emergency care in a private hospital in Lagos, Nigeria.BMC health services research · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundAetiology and outcomes of sepsis in sub-Saharan Africa (sSA) are poorly described; we performed a systematic review and meta-analysis to summarise the available data.
methodsSystematic searches of PubMed and Scopus were undertaken to identify prospective studies recruiting adults (> 13 years) with community-acquired sepsis in sSA post-2000. Random effects meta-analysis of in-hospital and 30-day mortality was undertaken and available aetiology data also summarised by random effects meta-analysis.
resultsFifteen studies of 2800 participants were identified. Inclusion criteria were heterogeneous. The majority of patients were HIV-infected, and Mycobacterium tuberculosis was the most common cause of blood stream infection where sought. Pooled in-hospital mortality for Sepsis-2-defined sepsis and severe sepsis was 19% (95% CI 12-29%) and 39% (95% CI 30-47%) respectively, and sepsis mortality was associated with the proportion of HIV-infected participants. Mortality and morbidity data beyond 30 days were absent.
conclusionsSepsis in sSA is dominated by HIV and tuberculosis, with poor outcomes. Optimal antimicrobial strategies, including the role of tuberculosis treatment, are unclear. Long-term outcome data are lacking. Standardised sepsis diagnostic criteria that are easily applied in low-resource settings are needed to establish an evidence base for sepsis management in sSA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.