Evidence map›Paper›PMID 31185892›Full record

ArticleBMC genomics2019

Evaluation of linkage disequilibrium, population structure, and genetic diversity in the U.S. peanut mini core collection.

Paul I Otyama, Andrew Wilkey, Roshan Kulkarni, Teshale Assefa, Ye Chu, Josh Clevenger, Dan J O'Connor, Graeme C Wright, Stanley W Dezern, Gregory E MacDonald and 4 more

Abstract read
In one paragraph

Article in BMC genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

14 authors.

Paul I OtyamaAgronomy Department, Iowa State University, Ames, IA, USA.
Andrew WilkeyORISE Fellow, Corn Insects and Crop Genetics Research Unit, USDA-ARS, Ames, IA, USA.
Roshan KulkarniAgronomy Department, Iowa State University, Ames, IA, USA.
Teshale AssefaAgronomy Department, Iowa State University, Ames, IA, USA.
Ye ChuInstitute of Plant Breeding, Genetics, and Genomics, University of Georgia, Tifton, GA, USA.
Josh ClevengerMars-Wrigley Confectionery, Center for Applied Genetic Technologies, Athens, GA, USA.
Dan J O'ConnorPeanut Company of Australia, Kingaroy, Qld, Australia.
Graeme C WrightPeanut Company of Australia, Kingaroy, Qld, Australia.
Stanley W DezernUniversity of Florida, Gainesville, FL, USA.
Gregory E MacDonaldUniversity of Florida, Gainesville, FL, USA.
Noelle L AnglinInternational Potato Center, Lima, Peru.
Ethalinda K S CannonComputer Science Department, Iowa State University, Ames, IA, USA.
Peggy Ozias-AkinsInstitute of Plant Breeding, Genetics, and Genomics, University of Georgia, Tifton, GA, USA.
Steven B CannonCorn Insects and Crop Genetics Research Unit, USDA - Agricultural Research Service, 1017 Crop Genome Lab 819 Wallace Rd, Ames, IA, 50011-4014, USA. steven.cannon@ars.usda.gov.ORCID http://orcid.org/0000-0003-2777-8034

Funding

Oak Ridge Institute for Science and Education NAThe Peanut Foundation 04-815-13USDA-ARS Project 5030-21000-062-00D
6 · The paper itself

Abstract

backgroundDue to the recent domestication of peanut from a single tetraploidization event, relatively little genetic diversity underlies the extensive morphological and agronomic diversity in peanut cultivars today. To broaden the genetic variation in future breeding programs, it is necessary to characterize germplasm accessions for new sources of variation and to leverage the power of genome-wide association studies (GWAS) to discover markers associated with traits of interest. We report an analysis of linkage disequilibrium (LD), population structure, and genetic diversity, and examine the ability of GWA to infer marker-trait associations in the U.S. peanut mini core collection genotyped with a 58 K SNP array.

resultsLD persists over long distances in the collection, decaying to r

conclusionsBased on GWA, population structure as well as additional simulation results, we find that the primary limitations of this collection for GWAS are a small collection size, significant remaining structure/genetic similarity and long LD blocks that limit the resolution of association mapping. These results can be used to improve GWAS in peanut in future studies - for example, by increasing the size and reducing structure in the collections used for GWAS.

Indexed as

Genetic VariationLinkage DisequilibriumArachisChromosomes, PlantGene FrequencyGenome-Wide Association StudyHaplotypesPhylogenyPolymorphism, Single NucleotidePopulation DynamicsGenetic diversityGenome wide associationLinkage disequilibriumPhylogenetic network treePopulation structure

Identifiers

PMID31185892
PMCPMC6558826

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.