ArticleProceedings. Biological sciences2019
Rare genetic variation and balanced polymorphisms are important for survival in global change conditions.
Article in Proceedings. Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Signals of Natural Selection across Regions of Low Recombination in Wild Populations of the Purple Sea Urchin, Strongylocentrotus purpuratus.Genome biology and evolution · 2026Article
- Morph-specific selection drives phenotypic divergence in color polymorphic tawny owls (Strix aluco) in Northern Europe.Communications biology · 2025Article
- Thermal Selection Shifts Genetic Diversity and Performance in Blue Mussel Juveniles.Evolutionary applications · 2025Article
- Article
- The Sixth Mass Extinction and Amphibian Species Sustainability Through Reproduction and Advanced Biotechnologies, Biobanking of Germplasm and Somatic Cells, and Conservation Breeding Programs (RBCs).Animals : an open access journal from MDPI · 2024Review
- Selection Shapes the Genomic Landscape of Introgressed Ancestry in a Pair of Sympatric Sea Urchin Species.Genome biology and evolution · 2024Article
- Consequences of domestication in eastern oyster: Insights from whole genomic analyses.Evolutionary applications · 2024Article
- Ecological Civilisation and Amphibian Sustainability through Reproduction Biotechnologies, Biobanking, and Conservation Breeding Programs (RBCs).Animals : an open access journal from MDPI · 2024Review
- Genomics for monitoring and understanding species responses to global climate change.Nature reviews. Genetics · 2024Review
- Balancing selection and candidate loci for survival and growth during larval development in the Mediterranean mussel, Mytilus galloprovincialis.G3 (Bethesda, Md.) · 2023Article
- Population-specific vulnerability to ocean change in a multistressor environment.Science advances · 2023Article
- Article
- Experimental evolution reveals the synergistic genomic mechanisms of adaptation to ocean warming and acidification in a marine copepod.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Genetic changes in larval oysters are more abundant and dynamic than can be explained by rare events or error: a response to Hedgecock (2022).Proceedings. Biological sciences · 2022Article
- No evidence for temporally balanced selection on larval Pacific oystersProceedings. Biological sciences · 2022Article
- Applying genomics in assisted migration under climate change: Framework, empirical applications, and case studies.Evolutionary applications · 2022Review
- Temporally balanced selection during development of larval Pacific oysters (Proceedings. Biological sciences · 2021Article
- Larval development in the Pacific oyster and the impacts of ocean acidification: Differential genetic effects in wild and domesticated stocks.Evolutionary applications · 2021Article
- Natural COEvolutionary applications · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Standing genetic variation is important for population persistence in extreme environmental conditions. While some species may have the capacity to adapt to predicted average future global change conditions, the ability to survive extreme events is largely unknown. We used single-generation selection experiments on hundreds of thousands of Strongylocentrotus purpuratus sea urchin larvae generated from wild-caught adults to identify adaptive genetic variation responsive to moderate (pH 8.0) and extreme (pH 7.5) low-pH conditions. Sequencing genomic DNA from pools of larvae, we identified consistent changes in allele frequencies across replicate cultures for each pH condition and observed increased linkage disequilibrium around selected loci, revealing selection on recombined standing genetic variation. We found that loci responding uniquely to either selection regime were at low starting allele frequencies while variants that responded to both pH conditions (11.6% of selected variants) started at high frequencies. Loci under selection performed functions related to energetics, pH tolerance, cell growth and actin/cytoskeleton dynamics. These results highlight that persistence in future conditions will require two classes of genetic variation: common, pH-responsive variants maintained by balancing selection in a heterogeneous environment, and rare variants, particularly for extreme conditions, that must be maintained by large population sizes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.