Evidence map›Paper›PMID 31185581›Full record

ReviewInternational journal of molecular sciences2019

Pathophysiology and Diagnosis of ALS: Insights from Advances in Neurophysiological Techniques.

Mehdi A J van den Bos, Nimeshan Geevasinga, Mana Higashihara, Parvathi Menon, Steve Vucic

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 3 pooled it
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 3 syntheses or guidelines pooled it, 142 citations in OpenAlex.

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  9. Clinical utility and prospective of TMS-EEG: Updated review from an international expert group.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mehdi A J van den BosWestern Clinical School, University of Sydney, Sydney 2145, Australia. mehdivandenbos@gmail.com.ORCID 0000-0003-0381-917X
Nimeshan GeevasingaWestern Clinical School, University of Sydney, Sydney 2145, Australia. nimesh84@hotmail.com.
Mana HigashiharaWestern Clinical School, University of Sydney, Sydney 2145, Australia. mana_higashihara@hotmail.com.ORCID 0000-0001-8015-2028
Parvathi MenonWestern Clinical School, University of Sydney, Sydney 2145, Australia. parmenon2010@gmail.com.
Steve VucicWestern Clinical School, University of Sydney, Sydney 2145, Australia. steve.vucic@sydney.edu.au.
The University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal neurodegenerative disorder of the motor neurons, characterized by focal onset of muscle weakness and incessant disease progression. While the presence of concomitant upper and lower motor neuron signs has been recognized as a pathognomonic feature of ALS, the pathogenic importance of upper motor neuron dysfunction has only been recently described. Specifically, transcranial magnetic stimulation (TMS) techniques have established cortical hyperexcitability as an important pathogenic mechanism in ALS, correlating with neurodegeneration and disease spread. Separately, ALS exhibits a heterogeneous clinical phenotype that may lead to misdiagnosis, particularly in the early stages of the disease process. Cortical hyperexcitability was shown to be a robust diagnostic biomarker if ALS, reliably differentiating ALS from neuromuscular mimicking disorders. The present review will provide an overview of key advances in the understanding of ALS pathophysiology and diagnosis, focusing on the importance of cortical hyperexcitability and its relationship to advances in genetic and molecular processes implicated in ALS pathogenesis.

Indexed as

Cortical ExcitabilityAmyotrophic Lateral SclerosisElectroencephalographyHumansTranscranial Magnetic StimulationALScortical hyperexcitabilityglutamate excitotoxicityTMS

Identifiers

PMID31185581
PMCPMC6600525
OpenAlexW2948061631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.