ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2019
Brain function during stages of working memory in schizophrenia and psychotic bipolar disorder.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Shared Genetic Networks in Schizophrenia and Bipolar Disorder: Hippocampal Volume-Mediated Neurobiological Mechanisms.Schizophrenia bulletin · 2026Article
- Dynamic frontoparietal flexibility and cognitive dysfunction in schizophrenia: disentangling the roles of symptom burden and childhood trauma.Psychological medicine · 2026Article
- Working memory network dysfunction in bipolar I vs. bipolar II disorder: a systematic review of task-fMRI evidence.Frontiers in psychiatry · 2026Review
- Cerebellar dysconnectivity in schizophrenia spectrum: task-based functional connectivity analysis and cognitive stratification.Frontiers in psychiatry · 2026Article
- Impaired visuospatial working memory but preserved attentional control in bipolar disorder.Psychological medicine · 2025Article
- NEK4: prediction of available drug targets and common genetic linkages in bipolar disorder and major depressive disorder.Frontiers in psychiatry · 2025Article
- Static and Dynamic Dysconnectivity in Early Psychosis: Relationship With Symptom Dimensions.Schizophrenia bulletin · 2024Article
- A prefrontal thalamocortical readout for conflict-related executive dysfunction in schizophrenia.Cell reports. Medicine · 2024Article
- Divergent pattern of functional connectivity within the dorsal attention network differentiates schizophrenia and bipolar disorder patients.Frontiers in psychiatry · 2024Article
- Dense attention network identifies EEG abnormalities during working memory performance of patients with schizophrenia.Frontiers in psychiatry · 2023Article
- Combining fMRI and DISC1 gene haplotypes to understand working memory-related brain activity in schizophrenia.Scientific reports · 2022Article
- Article
- Lower functional connectivity of white matter during rest and working memory tasks is associated with cognitive impairments in schizophrenia.Schizophrenia research · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Working memory (WM) is impaired in psychotic disorders and linked to functional outcome. Most neurobiological models emphasize prefrontal cortex (PFC) dysfunction in the etiology of WM impairment. However, WM is composed of multiple processes, including encoding and maintenance, and the delineation of the neurobiology of these sub-processes has not been well characterized in schizophrenia and psychotic bipolar disorder. Functional MRI was obtained during an event-related spatial delayed match-to-sample task from 58 healthy individuals, 72 individuals with schizophrenia and 41 people with bipolar I disorder with psychotic features in order to: 1) characterize neural responses during encoding, maintenance and retrieval stages of WM using complementary region-of-interest and whole brain approaches; 2) determine whether schizophrenia and psychotic bipolar disorder exhibit similar abnormalities in WM-related brain function; and 3) elucidate the associations between WM-related brain function, task performance, and neuropsychological functioning. Both schizophrenia and psychotic bipolar disorder groups showed encoding- and maintenance-related impairments in the posterior parietal cortex (PPC) and frontal eye fields (FEF). BOLD response in the PPC and FEF, during encoding and maintenance respectively, was associated with task performance independent of group. Additionally, encoding-related activation in the PPC correlated with general neuropsychological functioning independent of group. Only encoding-related activation in the right ventral striatum differed between schizophrenia and psychotic bipolar disorder; individuals with schizophrenia showed significantly lower activation than both psychotic bipolar disorder and healthy groups. Our results are consistent with emerging evidence implicating PPC dysfunction in WM impairment and suggest interventions targeting neural activation in PPC may improve WM and neuropsychological functioning across psychotic disorders.
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