ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2019
Post-mastectomy intensity modulated proton therapy after immediate breast reconstruction: Initial report of reconstruction outcomes and predictors of complications.
Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Conventional versus hypofractionated postmastectomy proton radiotherapy in the USA (MC1631): a randomised phase 2 trial.The Lancet. Oncology · 2023Trial
- Dose-Linear Energy Transfer Interactions Predict Capsular Contracture After Proton Postmastectomy Radiation Therapy.International journal of radiation oncology, biology, physics · 2026Article
- Treatment planning comparison of proton arc therapy and intensity modulated proton therapy for synchronous bilateral breast or chest wall and regional nodal irradiation.Physics and imaging in radiation oncology · 2026Article
- Breast cancer radiotherapy and the risk of lung injury: Advances and perspectives.Advances in radiotherapy & nuclear medicine · 2026Article
- Immediate 2-Stage breast reconstruction outcomes after proton or photon postmastectomy radiotherapy.Clinical and translational radiation oncology · 2025Article
- Proton therapy for breast cancer: Reducing toxicity.Thoracic cancer · 2024Review
- Dosimetric Correlation of Acute Radiation Dermatitis in Patients With Breast Cancer Undergoing Hypofractionated Proton Beam Therapy Using Pencil Beam Scanning.Journal of breast cancer · 2024Article
- Outcomes of whole breast radiation therapy in Asian breast cancer patients with prior cosmetic implants.Breast cancer (Tokyo, Japan) · 2024Article
- Breast Reconstruction Complications After Postmastectomy Proton Radiation Therapy for Breast Cancer.Advances in radiation oncology · 2024Article
- Proton therapy for reducing heart and cardiac substructure doses in Indian breast cancer patients.Radiation oncology journal · 2023Article
- The Potential of Proton Therapy for Locally Advanced Breast Cancer: Clinical and Technical Considerations.Current oncology (Toronto, Ont.) · 2023Review
- Reconstructive complications and early toxicity in breast cancer patients treated with proton-based postmastectomy radiation therapy.Frontiers in oncology · 2023Article
- The Role of Hypofractionation in Proton Therapy.Cancers · 2022Review
- Proton therapy for isolated local regional recurrence of breast cancer after mastectomy alone.Frontiers in oncology · 2022Article
- The Impact of Adjuvant Radiotherapy on Immediate Implant-based Breast Reconstruction Surgical and Satisfaction Outcomes: A Systematic Review and Meta-analysis.Plastic and reconstructive surgery. Global open · 2021Article
- Proton Therapy for Breast Cancer: A Consensus Statement From the Particle Therapy Cooperative Group Breast Cancer Subcommittee.International journal of radiation oncology, biology, physics · 2021Review
- Selection criteria for early breast cancer patients in the DBCG proton trial - The randomised phase III trial strategy.Clinical and translational radiation oncology · 2021Article
- Particle Therapy for Breast Cancer: Benefits and Challenges.Frontiers in oncology · 2021Review
- Personalization in Modern Radiation Oncology: Methods, Results and Pitfalls. Personalized Interventions and Breast Cancer.Frontiers in oncology · 2021Review
- Post-mastectomy radiation therapy in breast reconstruction: a patterns of care study of the Korean Radiation Oncology Group.Radiation oncology journal · 2020Article
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Authors and funding
16 authors.
Funding
Abstract
purposeTo report reconstructive outcomes of patients treated with post-mastectomy intensity modulated proton therapy (IMPT) following immediate breast reconstruction (IBR). MATERIALS AND
methodsConsecutive women with breast cancer who underwent implant-based IBR and post-mastectomy IMPT were included. Clinical characteristics, dosimetry, and acute toxicity were collected prospectively and reconstruction complications retrospectively.
resultsFifty-one women were treated between 2015 and 2017. Forty-two had bilateral reconstruction with unilateral IMPT. The non-irradiated contralateral breasts served as controls. Conventional fractionation (median 50 Gy/25 fractions) was administered in 37 (73%) and hypofractionation (median 40.5 Gy/15 fractions) in 14 (27%) patients. Median mean heart, ipsilateral lung V20Gy, and CTV-IMN V95% were 0.6 Gy, 13.9%, and 97.4%. Maximal acute dermatitis grade was 1 in 32 (63%), 2 in 17 (33%), and 3 in 2 (4%) patients. Surgical site infection (hazard ratio [HR] 13.19, 95% confidence interval [CI] 1.67-104.03, p = 0.0012), and unplanned surgical intervention (HR 9.86, 95% CI 1.24-78.67, p = 0.0068) were more common in irradiated breasts. Eight of 51 irradiated breasts and 2 of 42 non-irradiated breasts had reconstruction failure (HR 3.59, 95% CI 0.78-16.41, p = 0.084). Among irradiated breasts, hypofractionation was significantly associated with reconstruction failure (HR 4.99, 95% CI 1.24-20.05, p = 0.024), as was older patient age (HR 1.14, 95% CI 1.05-1.24, p = 0.002).
conclusionsIMPT following IBR spared underlying organs and had low rates of acute toxicity. Reconstruction complications are more common in irradiated breasts, and reconstructive outcomes appear comparable with photon literature. Hypofractionation was associated with higher reconstruction failure rates. Further investigation of optimal dose-fractionation after IBR is needed.
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