Trial reportPloS one2019
Cost of hospital care for the older adults according to their level of frailty. A cohort study in the Lazio region, Italy.
Trial report in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Cost of illness analysis of frailty for older adults: a systematic review and meta-analysis.European geriatric medicine · 2025Pooled it
- International depiction of the cost of functional independence limitations among older adults living in the community: a systematic review and cost-of-impairment study.BMC geriatrics · 2022Pooled it
- The impact of interventions on management of frailty in hospitalized frail older adults: a systematic review and meta-analysis.BMC geriatrics · 2020Pooled it
- Decentralized example of a randomized clinical trial: OM-85 use in older patients at risk of respiratory tract infections.Aging clinical and experimental research · 2026Trial
- Frailty identifies early and non-cardiac healthcare utilization after cardiovascular hospitalization.Frontiers in cardiovascular medicine · 2026Article
- Care Patterns, Outcomes, and Costs in Peripheral T-Cell Lymphoma Patients with First-Line Treatment in Routine Clinical Practice in Europe.Journal of blood medicine · 2026Article
- Undernourished and Undertreated: The Role of Nutritional Care in Geriatric Hospital Outcomes.Nutrients · 2025Article
- RhoA/rho kinase pathway activation in age-associated endothelial cell dysfunction and thrombosis.Journal of cellular and molecular medicine · 2024Review
- Frailty in an Adult Acute Hospital Population: Predictors, Prevalence, and Outcomes.International journal of environmental research and public health · 2024Article
- The association between healthcare expenditures and potentially inappropriate medication use in hospitalized older adults in Ethiopia.BMC geriatrics · 2024Observational
- Relationship of frailty status with health resource use and healthcare costs in the population aged 65 and over in Catalonia.European journal of ageing · 2023Article
- Exploratory Factor Analysis (EFA) of the Short Functional Geriatric Evaluation (SFGE) to Assess the Multidimensionality of Frailty in Community-Dwelling Older Adults.International journal of environmental research and public health · 2023Article
- Zoledronate Extends Health Span and Survival via the Mevalonate Pathway in a FOXO-dependent Manner.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Assessment of Physical Fitness and Risk Factors for the Occurrence of the Frailty Syndrome among Social Welfare Homes' Residents over 60 Years of Age in Poland.International journal of environmental research and public health · 2022Article
- Association Between Frailty and Inpatient Services Utilization Among Older Adults in Rural China: The Mediating Role of Multimorbidity.Frontiers in medicine · 2022Article
- Predicting and improving hospital outcomes for older adults.International psychogeriatrics · 2021Article
- Assessing the Impact of A Community-Based Pro-Active Monitoring Program Addressing the need for Care of Community-Dwelling Citizens aged more than 80: Protocol for a Prospective Pragmatic Trial and Results of the Baseline Assessment.Translational medicine @ UniSa · 2020Article
- Health and care service utilisation and cost over the life-span: a descriptive analysis of population data.BMC health services research · 2020Article
- Polypharmacy Is Associated with Frailty, Nutritional Risk and Chronic Disease in Chilean Older Adults: Remarks from PIEI-ES Study.Clinical interventions in aging · 2020Article
- Predictors of Emergency Room Access and Not Urgent Emergency Room Access by the Frail Older Adults.Frontiers in public healthObservational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe increasing burden of chronic diseases associated with the ageing of the European population constitutes one of the main challenges for the welfare systems in developed western countries, especially through its impact on the use of hospital services and the cost of care. This study aims at evaluating the cost of hospital care for older adults living in the Lazio Region, Italy, according to their level of frailty.
methodsSince 2014 a longitudinal randomized cohort study has been carried out on a sample consisting of 1280 older adults aged over 64 years resident in the Lazio region (Italy), with their being evaluated for multidimensional frailty. Accesses to Hospital Services (acute care and Day Hospital care admissions and Emergency Room accesses) during the first year after enrolment, as well as the related costs have been recorded through a regional database. Costs have been stratified on the basis of the state of frailty.
resultsThe analysis of hospital services and costs highlights the role played by pre-frail individuals who generated 49.3% of the hospital care cumulative costs. Hospital Admission (HA) costs arising from robust and pre-frail subjects are 70% of the total HA costs. Pre-frail individuals also showed the highest average HA cost per person/year (7062.89 Euros). The main determinant of the highest HA costs was given by the number of HAs during the follow-up (multivariate linear regression, ß coefficient = 0.319; p<0.001), which was higher among pre-frail individuals than in any other group of patients.
conclusionsPre-frail individuals generated the highest cost for hospital care in a sample of representative subjects living in an Italian Region with a low rate of community care services, as is the case in the Lazio region. Assessment of the multidimensional frailty of older adults permits a better definition of the important target of the pre-frail population as the main category within which interventions to prevent or mitigate frailty should be carried out.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.