Evidence map›Paper›PMID 31185030›Full record

Trial reportPloS one2019

Circulation of chikungunya virus East/Central/South African lineage in Rio de Janeiro, Brazil.

Joilson Xavier, Marta Giovanetti, Vagner Fonseca, Julien Thézé, Tiago Gräf, Allison Fabri, Jaqueline Goes de Jesus, Marcos Cesar Lima de Mendonça, Cintia Damasceno Dos Santos Rodrigues, Maria Angélica Mares-Guia and 15 more

Abstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. High capacity of BrazilianbioRxiv : the preprint server for biology · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Joilson XavierLaboratório de Patologia Experimental, Instituto Gonçalo Moniz/Fiocruz, Salvador, Bahia, Brazil.ORCID 0000-0003-3916-2018
Marta GiovanettiLaboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Vagner FonsecaLaboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Julien ThézéDepartment of Zoology, University of Oxford, Oxford, United Kingdom.
Tiago GräfDepartamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Brazil.
Allison FabriLaboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Jaqueline Goes de JesusLaboratório de Patologia Experimental, Instituto Gonçalo Moniz/Fiocruz, Salvador, Bahia, Brazil.ORCID 0000-0002-5404-272X
Marcos Cesar Lima de MendonçaLaboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Cintia Damasceno Dos Santos RodriguesLaboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Maria Angélica Mares-GuiaLaboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Carolina Cardoso Dos SantosLaboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Stephane Fraga de Oliveira TostaLaboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Darlan CandidoDepartment of Zoology, University of Oxford, Oxford, United Kingdom.
Rita Maria Ribeiro NogueiraLaboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
André Luiz de AbreuSecretaria de Vigilância em Saúde, Ministério da Saúde, Brasília, Distrito Federal, Brazil.
Wanderson Kleber OliveiraSecretaria de Vigilância em Saúde, Ministério da Saúde, Brasília, Distrito Federal, Brazil.
Carlos F Campelo de AlbuquerqueOrganização Pan-Americana da Saúde/Organização Mundial da Saúde, Brasília, Distrito Federal, Brazil.
Alexandre ChieppeSuperintendência de Vigilância do Estado, Rio de Janeiro, Brazil.
Tulio de OliveiraKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Patrícia BrasilInstituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Brazil.
Guilherme CalvetInstituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Brazil.
Patrícia Carvalho SequeiraLaboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Nuno Rodrigues FariaDepartment of Zoology, University of Oxford, Oxford, United Kingdom.
Ana Maria Bispo de FilippisLaboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Luiz Carlos Junior AlcantaraLaboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.ORCID 0000-0002-6769-9931

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emergence of chikungunya virus (CHIKV) has raised serious concerns due to the virus' rapid dissemination into new geographic areas and the clinical features associated with infection. To better understand CHIKV dynamics in Rio de Janeiro, we generated 11 near-complete genomes by means of real-time portable nanopore sequencing of virus isolates obtained directly from clinical samples. To better understand CHIKV dynamics in Rio de Janeiro, we generated 11 near-complete genomes by means of real-time portable nanopore sequencing of virus isolates obtained directly from clinical samples. Our phylogenetic reconstructions indicated the circulation of the East-Central-South-African (ECSA) lineage in Rio de Janeiro. Time-measured phylogenetic analysis combined with CHIKV notified case numbers revealed the ECSA lineage was introduced in Rio de Janeiro around June 2015 (95% Bayesian credible interval: May to July 2015) indicating the virus was circulating unnoticed for 5 months before the first reports of CHIKV autochthonous transmissions in Rio de Janeiro, in November 2015. These findings reinforce that continued genomic surveillance strategies are needed to assist in the monitoring and understanding of arbovirus epidemics, which might help to attenuate public health impact of infectious diseases.

Indexed as

High-Throughput Nucleotide SequencingPhylogenyAdultAfricaBrazilChikungunya FeverChikungunya virusFemaleHumansMaleMiddle Aged

Identifiers

PMID31185030
PMCPMC6559644

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.