Evidence map›Paper›PMID 31185029›Full record

ArticlePloS one2019

Efficacy of a novel endoscopically deliverable muco-adhesive hemostatic powder in an acute gastric bleeding porcine model.

ByoungWook Bang, Eunhye Lee, JinHee Maeng, Keunsu Kim, Joo Ha Hwang, Suong-Hyu Hyon, Woogi Hyon, Don Haeng Lee

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Effective, safe and efficient porcine model of Forrest Ib bleeding gastric and colonic ulcers.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023
    Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

ByoungWook BangDivision of Gastroenterology, Department of Internal Medicine, Inha University College of Medicine, Incheon, Republic of Korea.
Eunhye LeeUtah-Inha DDS and Advanced Therapeutics Research Center, Incheon, Republic of Korea.
JinHee MaengUtah-Inha DDS and Advanced Therapeutics Research Center, Incheon, Republic of Korea.
Keunsu KimUtah-Inha DDS and Advanced Therapeutics Research Center, Incheon, Republic of Korea.
Joo Ha HwangDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, California, United States of America.
Suong-Hyu HyonBMG Incorporated, Kyoto, Japan.
Woogi HyonBMG Incorporated, Kyoto, Japan.
Don Haeng LeeDivision of Gastroenterology, Department of Internal Medicine, Inha University College of Medicine, Incheon, Republic of Korea.ORCID 0000-0003-0397-302X
Inha University · KRBMG (Japan) · JPJapan Advanced Institute of Science and Technology · JPStanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the effectiveness of new hemostatic adhesive powder (UI-EWD) in a swine mode of acute gastric bleeding. Gastric ulcer bleeding was induced endoscopically at two locations in each of eight heparinized mini-pigs. UI-EWD and saline were sprayed endoscopically in the experimental (n = 5) and control groups (n = 3), respectively. The hemostatic effect and hydrogel persistence on ulcers were periodically evaluated endoscopically. Initial hemostasis was achieved successfully in all lesions in the experimental group. Follow-up endoscopy showed minor delayed bleeding in 10% at 6 hours in the experimental group, whereas re-bleeding was observed in 50% at 6 hours in the control group. UI-EWD gel persisted at 90%, 80%, and 50% of ulcer bases at 6, 18, and 42 hours post-application, respectively. This study suggests that muco-adhesive UI-EWD may be effective in the endoscopic treatment of active ulcer bleeding.

Indexed as

Drug Delivery SystemsEndoscopyAdhesivenessAnimalsDisease Models, AnimalGastric MucosaGastrointestinal HemorrhageHemostasisHemostaticsPowdersSwineHemostaticsPowders

Identifiers

PMID31185029
PMCPMC6559629
OpenAlexW2952884046

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.