Evidence map›Paper›PMID 31185027›Full record

Trial reportPloS one2019

Heritability of semantic verbal fluency task using time-interval analysis.

T P Taporoski, N E Duarte, S Pompéia, A Sterr, L M Gómez, R O Alvim, A R V R Horimoto, J E Krieger, H Vallada, A C Pereira and 2 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Genome-Wide Epistatic Network Analyses of Semantic Fluency in Older Adults.International journal of molecular sciences · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

T P TaporoskiInstitute of Psychiatry (LIM-23), Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
N E DuarteLaboratory of Genetics and Molecular Cardiology, Heart Institute, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil.
S PompéiaDepartment of Psychobiology, Universidade Federal de São Paulo-Escola Paulista de Medicina, São Paulo, SP, Brazil.
A SterrDepartment of Psychological Sciences, University of Surrey, Guildford, Surrey, United Kingdom.
L M GómezLaboratory of Genetics and Molecular Cardiology, Heart Institute, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil.
R O AlvimLaboratory of Genetics and Molecular Cardiology, Heart Institute, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil.
A R V R HorimotoLaboratory of Genetics and Molecular Cardiology, Heart Institute, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil.
J E KriegerLaboratory of Genetics and Molecular Cardiology, Heart Institute, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil.
H ValladaInstitute of Psychiatry (LIM-23), Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
A C PereiraLaboratory of Genetics and Molecular Cardiology, Heart Institute, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil.
M von SchantzInstitute of Psychiatry (LIM-23), Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.ORCID 0000-0002-9911-9436
A B NegrãoInstitute of Psychiatry (LIM-23), Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Individual variability in word generation is a product of genetic and environmental influences. The genetic effects on semantic verbal fluency were estimated in 1,735 participants from the Brazilian Baependi Heart Study. The numbers of exemplars produced in 60 s were broken down into time quartiles because of the involvement of different cognitive processes-predominantly automatic at the beginning, controlled/executive at the end. Heritability in the unadjusted model for the 60-s measure was 0.32. The best-fit model contained age, sex, years of schooling, and time of day as covariates, giving a heritability of 0.21. Schooling had the highest moderating effect. The highest heritability (0.17) was observed in the first quartile, decreasing to 0.09, 0.12, and 0.0003 in the following ones. Heritability for average production starting point (intercept) was 0.18, indicating genetic influences for automatic cognitive processes. Production decay (slope), indicative of controlled processes, was not significant. The genetic influence on different quartiles of the semantic verbal fluency test could potentially be exploited in clinical practice and genome-wide association studies.

Indexed as

CognitionGenome-Wide Association StudySemanticsVerbal BehaviorAdolescentAdultAgedFemaleHumansMaleMiddle Aged

Identifiers

PMID31185027
PMCPMC6559646

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.