Evidence map›Paper›PMID 31184586›Full record

ArticleeLife2019

The interplay at the replisome mitigates the impact of oxidative damage on the genetic integrity of hyperthermophilic

Tom Killelea, Adeline Palud, Farida Akcha, Mélanie Lemor, Stephane L'haridon, Anne Godfroy, Ghislaine Henneke

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Archaeal DNA Replication.Annual review of microbiology · 2020
    Review
  6. Article
  7. Genetic Control of Oxidative Mutagenesis inJournal of bacteriology · 2020
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Tom KilleleaUniv Brest, Ifremer, CNRS, Laboratoire de Microbiologie des Environnements Extrêmes, Plouzané, France.ORCID 0000-0003-0974-8034
Adeline PaludUniv Brest, Ifremer, CNRS, Laboratoire de Microbiologie des Environnements Extrêmes, Plouzané, France.
Farida AkchaLaboratoire d'Ecotoxicologie, Ifremer, Nantes, France.
Mélanie LemorUniv Brest, Ifremer, CNRS, Laboratoire de Microbiologie des Environnements Extrêmes, Plouzané, France.
Stephane L'haridonUniv Brest, Ifremer, CNRS, Laboratoire de Microbiologie des Environnements Extrêmes, Plouzané, France.
Anne GodfroyUniv Brest, Ifremer, CNRS, Laboratoire de Microbiologie des Environnements Extrêmes, Plouzané, France.
Ghislaine HennekeUniv Brest, Ifremer, CNRS, Laboratoire de Microbiologie des Environnements Extrêmes, Plouzané, France.ORCID 0000-0002-2985-5526
Centre National de la Recherche Scientifique · FRIfremer · FR

Funding

Agence Nationale de la Recherche ANR-10-JCJC-1501-01
6 · The paper itself

Abstract

8-oxodeoxyguanosine (8-oxodG), a major oxidised base modification, has been investigated to study its impact on DNA replication in hyperthermophilic

Indexed as

DNA Damage8-Hydroxy-2'-DeoxyguanosineArchaeaDNA, ArchaealDNA-Directed DNA PolymeraseDNA RepairDNA ReplicationGenome, ArchaealModels, GeneticMutationOxidative StressProtein Biosynthesis8-Hydroxy-2'-DeoxyguanosineDNA, ArchaealDNA-Directed DNA Polymerase8-oxodeoxyguanosineaccessory factorsbiochemistrychemical biologychromosomesDNA polymerasesDNA replicationgene expressionoxidative stressPyrococcus abyssi

Identifiers

PMID31184586
PMCPMC6559790
OpenAlexW2949703574

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.