Evidence map›Paper›PMID 31184561›Full record

ReviewRadiology2019

PI-RADS Steering Committee: The PI-RADS Multiparametric MRI and MRI-directed Biopsy Pathway.

Anwar R Padhani, Jelle Barentsz, Geert Villeirs, Andrew B Rosenkrantz, Daniel J Margolis, Baris Turkbey, Harriet C Thoeny, François Cornud, Masoom A Haider, Katarzyna J Macura and 3 more

Registry-linked trialAbstract readReview
In one paragraph

Review in Radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07386496 (The Role of 18F-PSMA PET in Prostate Cancer Diagnosis in Equivocal MRI), which is not on this map. Cited by 129 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07386496 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

The Role of 18F-PSMA PET in Prostate Cancer Diagnosis in Equivocal MRI: a Multi-center Randomised Controlled Trial

TypeinterventionalSponsorChinese University of Hong KongRan2026 to 2028Enrolled250ConditionsProstate CancerArmsMRI+PSMA-guided approach, MRI-guided approach
3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anwar R PadhaniFrom the Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Rickmansworth Rd, Northwood, Middlesex HA6 2RN, England (A.R.P.); Department of Radiology and Nuclear Medicine Radboud University Medical Center, Nijmegen, the Netherlands (J.B.); Department of Radiology, Ghent University Hospital, Ghent, Belgium (G.V.); Department of Radiology, NYU Langone Medical Center, New York, NY (A.B.R.); Weill Cornell Imaging, Cornell University, New York, NY (D.J.M.); Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Md (B.T.); Department of Radiology, Hôpital Cantonal de Fribourg HFR, University of Fribourg, Fribourg, Switzerland (H.C.T.); Paris Descartes University, Department of Radiology, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France (F.C.); University of Toronto, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada (M.A.H.); Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (K.J.M.); Department of Radiology, Brigham and Women's Hospital, Boston, Mass (C.M.T.); Department of Radiology, University of Cincinnati, College of Medicine, Cincinnati, Ohio (S.V.); and Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Conn (J.C.W.).ORCID 0000-0002-5830-5777
Jelle BarentszFrom the Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Rickmansworth Rd, Northwood, Middlesex HA6 2RN, England (A.R.P.); Department of Radiology and Nuclear Medicine Radboud University Medical Center, Nijmegen, the Netherlands (J.B.); Department of Radiology, Ghent University Hospital, Ghent, Belgium (G.V.); Department of Radiology, NYU Langone Medical Center, New York, NY (A.B.R.); Weill Cornell Imaging, Cornell University, New York, NY (D.J.M.); Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Md (B.T.); Department of Radiology, Hôpital Cantonal de Fribourg HFR, University of Fribourg, Fribourg, Switzerland (H.C.T.); Paris Descartes University, Department of Radiology, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France (F.C.); University of Toronto, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada (M.A.H.); Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (K.J.M.); Department of Radiology, Brigham and Women's Hospital, Boston, Mass (C.M.T.); Department of Radiology, University of Cincinnati, College of Medicine, Cincinnati, Ohio (S.V.); and Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Conn (J.C.W.).
Geert VilleirsFrom the Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Rickmansworth Rd, Northwood, Middlesex HA6 2RN, England (A.R.P.); Department of Radiology and Nuclear Medicine Radboud University Medical Center, Nijmegen, the Netherlands (J.B.); Department of Radiology, Ghent University Hospital, Ghent, Belgium (G.V.); Department of Radiology, NYU Langone Medical Center, New York, NY (A.B.R.); Weill Cornell Imaging, Cornell University, New York, NY (D.J.M.); Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Md (B.T.); Department of Radiology, Hôpital Cantonal de Fribourg HFR, University of Fribourg, Fribourg, Switzerland (H.C.T.); Paris Descartes University, Department of Radiology, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France (F.C.); University of Toronto, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada (M.A.H.); Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (K.J.M.); Department of Radiology, Brigham and Women's Hospital, Boston, Mass (C.M.T.); Department of Radiology, University of Cincinnati, College of Medicine, Cincinnati, Ohio (S.V.); and Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Conn (J.C.W.).
Andrew B RosenkrantzFrom the Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Rickmansworth Rd, Northwood, Middlesex HA6 2RN, England (A.R.P.); Department of Radiology and Nuclear Medicine Radboud University Medical Center, Nijmegen, the Netherlands (J.B.); Department of Radiology, Ghent University Hospital, Ghent, Belgium (G.V.); Department of Radiology, NYU Langone Medical Center, New York, NY (A.B.R.); Weill Cornell Imaging, Cornell University, New York, NY (D.J.M.); Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Md (B.T.); Department of Radiology, Hôpital Cantonal de Fribourg HFR, University of Fribourg, Fribourg, Switzerland (H.C.T.); Paris Descartes University, Department of Radiology, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France (F.C.); University of Toronto, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada (M.A.H.); Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (K.J.M.); Department of Radiology, Brigham and Women's Hospital, Boston, Mass (C.M.T.); Department of Radiology, University of Cincinnati, College of Medicine, Cincinnati, Ohio (S.V.); and Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Conn (J.C.W.).ORCID 0000-0002-1558-5350
Daniel J MargolisFrom the Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Rickmansworth Rd, Northwood, Middlesex HA6 2RN, England (A.R.P.); Department of Radiology and Nuclear Medicine Radboud University Medical Center, Nijmegen, the Netherlands (J.B.); Department of Radiology, Ghent University Hospital, Ghent, Belgium (G.V.); Department of Radiology, NYU Langone Medical Center, New York, NY (A.B.R.); Weill Cornell Imaging, Cornell University, New York, NY (D.J.M.); Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Md (B.T.); Department of Radiology, Hôpital Cantonal de Fribourg HFR, University of Fribourg, Fribourg, Switzerland (H.C.T.); Paris Descartes University, Department of Radiology, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France (F.C.); University of Toronto, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada (M.A.H.); Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (K.J.M.); Department of Radiology, Brigham and Women's Hospital, Boston, Mass (C.M.T.); Department of Radiology, University of Cincinnati, College of Medicine, Cincinnati, Ohio (S.V.); and Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Conn (J.C.W.).ORCID 0000-0001-8212-707X
Baris TurkbeyFrom the Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Rickmansworth Rd, Northwood, Middlesex HA6 2RN, England (A.R.P.); Department of Radiology and Nuclear Medicine Radboud University Medical Center, Nijmegen, the Netherlands (J.B.); Department of Radiology, Ghent University Hospital, Ghent, Belgium (G.V.); Department of Radiology, NYU Langone Medical Center, New York, NY (A.B.R.); Weill Cornell Imaging, Cornell University, New York, NY (D.J.M.); Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Md (B.T.); Department of Radiology, Hôpital Cantonal de Fribourg HFR, University of Fribourg, Fribourg, Switzerland (H.C.T.); Paris Descartes University, Department of Radiology, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France (F.C.); University of Toronto, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada (M.A.H.); Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (K.J.M.); Department of Radiology, Brigham and Women's Hospital, Boston, Mass (C.M.T.); Department of Radiology, University of Cincinnati, College of Medicine, Cincinnati, Ohio (S.V.); and Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Conn (J.C.W.).ORCID 0000-0003-0853-6494
Harriet C ThoenyFrom the Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Rickmansworth Rd, Northwood, Middlesex HA6 2RN, England (A.R.P.); Department of Radiology and Nuclear Medicine Radboud University Medical Center, Nijmegen, the Netherlands (J.B.); Department of Radiology, Ghent University Hospital, Ghent, Belgium (G.V.); Department of Radiology, NYU Langone Medical Center, New York, NY (A.B.R.); Weill Cornell Imaging, Cornell University, New York, NY (D.J.M.); Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Md (B.T.); Department of Radiology, Hôpital Cantonal de Fribourg HFR, University of Fribourg, Fribourg, Switzerland (H.C.T.); Paris Descartes University, Department of Radiology, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France (F.C.); University of Toronto, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada (M.A.H.); Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (K.J.M.); Department of Radiology, Brigham and Women's Hospital, Boston, Mass (C.M.T.); Department of Radiology, University of Cincinnati, College of Medicine, Cincinnati, Ohio (S.V.); and Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Conn (J.C.W.).
François CornudFrom the Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Rickmansworth Rd, Northwood, Middlesex HA6 2RN, England (A.R.P.); Department of Radiology and Nuclear Medicine Radboud University Medical Center, Nijmegen, the Netherlands (J.B.); Department of Radiology, Ghent University Hospital, Ghent, Belgium (G.V.); Department of Radiology, NYU Langone Medical Center, New York, NY (A.B.R.); Weill Cornell Imaging, Cornell University, New York, NY (D.J.M.); Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Md (B.T.); Department of Radiology, Hôpital Cantonal de Fribourg HFR, University of Fribourg, Fribourg, Switzerland (H.C.T.); Paris Descartes University, Department of Radiology, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France (F.C.); University of Toronto, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada (M.A.H.); Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (K.J.M.); Department of Radiology, Brigham and Women's Hospital, Boston, Mass (C.M.T.); Department of Radiology, University of Cincinnati, College of Medicine, Cincinnati, Ohio (S.V.); and Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Conn (J.C.W.).
Masoom A HaiderFrom the Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Rickmansworth Rd, Northwood, Middlesex HA6 2RN, England (A.R.P.); Department of Radiology and Nuclear Medicine Radboud University Medical Center, Nijmegen, the Netherlands (J.B.); Department of Radiology, Ghent University Hospital, Ghent, Belgium (G.V.); Department of Radiology, NYU Langone Medical Center, New York, NY (A.B.R.); Weill Cornell Imaging, Cornell University, New York, NY (D.J.M.); Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Md (B.T.); Department of Radiology, Hôpital Cantonal de Fribourg HFR, University of Fribourg, Fribourg, Switzerland (H.C.T.); Paris Descartes University, Department of Radiology, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France (F.C.); University of Toronto, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada (M.A.H.); Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (K.J.M.); Department of Radiology, Brigham and Women's Hospital, Boston, Mass (C.M.T.); Department of Radiology, University of Cincinnati, College of Medicine, Cincinnati, Ohio (S.V.); and Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Conn (J.C.W.).ORCID 0000-0002-7165-8315
Katarzyna J MacuraFrom the Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Rickmansworth Rd, Northwood, Middlesex HA6 2RN, England (A.R.P.); Department of Radiology and Nuclear Medicine Radboud University Medical Center, Nijmegen, the Netherlands (J.B.); Department of Radiology, Ghent University Hospital, Ghent, Belgium (G.V.); Department of Radiology, NYU Langone Medical Center, New York, NY (A.B.R.); Weill Cornell Imaging, Cornell University, New York, NY (D.J.M.); Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Md (B.T.); Department of Radiology, Hôpital Cantonal de Fribourg HFR, University of Fribourg, Fribourg, Switzerland (H.C.T.); Paris Descartes University, Department of Radiology, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France (F.C.); University of Toronto, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada (M.A.H.); Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (K.J.M.); Department of Radiology, Brigham and Women's Hospital, Boston, Mass (C.M.T.); Department of Radiology, University of Cincinnati, College of Medicine, Cincinnati, Ohio (S.V.); and Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Conn (J.C.W.).
Clare M TempanyFrom the Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Rickmansworth Rd, Northwood, Middlesex HA6 2RN, England (A.R.P.); Department of Radiology and Nuclear Medicine Radboud University Medical Center, Nijmegen, the Netherlands (J.B.); Department of Radiology, Ghent University Hospital, Ghent, Belgium (G.V.); Department of Radiology, NYU Langone Medical Center, New York, NY (A.B.R.); Weill Cornell Imaging, Cornell University, New York, NY (D.J.M.); Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Md (B.T.); Department of Radiology, Hôpital Cantonal de Fribourg HFR, University of Fribourg, Fribourg, Switzerland (H.C.T.); Paris Descartes University, Department of Radiology, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France (F.C.); University of Toronto, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada (M.A.H.); Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (K.J.M.); Department of Radiology, Brigham and Women's Hospital, Boston, Mass (C.M.T.); Department of Radiology, University of Cincinnati, College of Medicine, Cincinnati, Ohio (S.V.); and Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Conn (J.C.W.).
Sadhna VermaFrom the Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Rickmansworth Rd, Northwood, Middlesex HA6 2RN, England (A.R.P.); Department of Radiology and Nuclear Medicine Radboud University Medical Center, Nijmegen, the Netherlands (J.B.); Department of Radiology, Ghent University Hospital, Ghent, Belgium (G.V.); Department of Radiology, NYU Langone Medical Center, New York, NY (A.B.R.); Weill Cornell Imaging, Cornell University, New York, NY (D.J.M.); Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Md (B.T.); Department of Radiology, Hôpital Cantonal de Fribourg HFR, University of Fribourg, Fribourg, Switzerland (H.C.T.); Paris Descartes University, Department of Radiology, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France (F.C.); University of Toronto, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada (M.A.H.); Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (K.J.M.); Department of Radiology, Brigham and Women's Hospital, Boston, Mass (C.M.T.); Department of Radiology, University of Cincinnati, College of Medicine, Cincinnati, Ohio (S.V.); and Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Conn (J.C.W.).
Jeffrey C WeinrebFrom the Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Rickmansworth Rd, Northwood, Middlesex HA6 2RN, England (A.R.P.); Department of Radiology and Nuclear Medicine Radboud University Medical Center, Nijmegen, the Netherlands (J.B.); Department of Radiology, Ghent University Hospital, Ghent, Belgium (G.V.); Department of Radiology, NYU Langone Medical Center, New York, NY (A.B.R.); Weill Cornell Imaging, Cornell University, New York, NY (D.J.M.); Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Md (B.T.); Department of Radiology, Hôpital Cantonal de Fribourg HFR, University of Fribourg, Fribourg, Switzerland (H.C.T.); Paris Descartes University, Department of Radiology, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France (F.C.); University of Toronto, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada (M.A.H.); Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (K.J.M.); Department of Radiology, Brigham and Women's Hospital, Boston, Mass (C.M.T.); Department of Radiology, University of Cincinnati, College of Medicine, Cincinnati, Ohio (S.V.); and Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Conn (J.C.W.).

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

High-quality evidence shows that MRI in biopsy-naive men can reduce the number of men who need prostate biopsy and can reduce the number of diagnoses of clinically insignificant cancers that are unlikely to cause harm. In men with prior negative biopsy results who remain under persistent suspicion, MRI improves the detection and localization of life-threatening prostate cancer with greater clinical utility than the current standard of care, systematic transrectal US-guided biopsy. Systematic analyses show that MRI-directed biopsy increases the effectiveness of the prostate cancer diagnosis pathway. The incorporation of MRI-directed pathways into clinical care guidelines in prostate cancer detection has begun. The widespread adoption of the Prostate Imaging Reporting and Data System (PI-RADS) for multiparametric MRI data acquisition, interpretation, and reporting has promoted these changes in practice. The PI-RADS MRI-directed biopsy pathway enables the delivery of key diagnostic benefits to men suspected of having cancer based on clinical suspicion. Herein, the PI-RADS Steering Committee discusses how the MRI pathway should be incorporated into routine clinical practice and the challenges in delivering the positive health impacts needed by men suspected of having clinically significant prostate cancer.

Indexed as

Radiology Information SystemsHumansImage-Guided BiopsyMagnetic Resonance Imaging, InterventionalMaleMultiparametric Magnetic Resonance ImagingProstateProstatic Neoplasms

Identifiers

PMID31184561
PMCPMC6677282

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