Evidence map›Paper›PMID 31184507›Full record

ArticleAmerican journal of respiratory cell and molecular biology2019

A Novel AAV-mediated Gene Delivery System Corrects CFTR Function in Pigs.

Ashley L Cooney, Ian M Thornell, Brajesh K Singh, Viral S Shah, David A Stoltz, Paul B McCray, Joseph Zabner, Patrick L Sinn

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 37 citations in OpenAlex.

  1. Considerations for early life genetic therapies in cystic fibrosis.American journal of physiology. Lung cellular and molecular physiology · 2026
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  11. Progress in Respiratory Gene Therapy.Human gene therapy · 2022
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  17. Tissue and cell-type-specific transduction using rAAV vectors in lung diseases.Journal of molecular medicine (Berlin, Germany) · 2021
    Review
  18. Update in Pediatrics 2020.American journal of respiratory and critical care medicine · 2021
    Article
  19. New Therapies to Correct the Cystic Fibrosis Basic Defect.International journal of molecular sciences · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Ashley L CooneyStead Family Department of Pediatrics.ORCID 0000-0003-2717-9138
Ian M ThornellPappajohn Biomedical Institute.
Brajesh K SinghStead Family Department of Pediatrics.
Viral S ShahPappajohn Biomedical Institute.
David A StoltzPappajohn Biomedical Institute.
Paul B McCrayStead Family Department of Pediatrics.
Joseph ZabnerPappajohn Biomedical Institute.
Patrick L SinnStead Family Department of Pediatrics.
Gene Therapy Laboratory · FRUniversity of Iowa · US

Funding

Vector CoreP01HL051670 · NHLBI · UNIVERSITY OF IOWA · PI MCCRAY, PAUL B · 1993 to 2019
$36.5M
Respiratory virus infection in early cystic fibrosis lung diseaseP01HL091842 · NHLBI · UNIVERSITY OF IOWA · PI ZABNER, JOSEPH · 2008 to 2022
$34.2M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5M
Life-long phenotypic correction of CF airwaysR01HL133089 · NHLBI · UNIVERSITY OF IOWA · PI PATRICK L SINN · 2017 to 2026
$5.3M
Targeted integration of a DNA transposon-based nonviral vectorR01HL105821 · NHLBI · UNIVERSITY OF IOWA · PI SINN, PATRICK L · 2012 to 2016
$1.9M
NHLBI NIH HHS P01 HL051670NHLBI NIH HHS P01 HL091842NHLBI NIH HHS R01 HL105821NHLBI NIH HHS R01 HL133089NIDDK NIH HHS P30 DK054759
6 · The paper itself

Abstract

Cystic fibrosis is an autosomal-recessive disease that is caused by a mutant

Indexed as

Genetic TherapyAnimalsAnimals, NewbornCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorDependovirusDNA Transposable ElementsGene Knockout TechniquesGenes, SyntheticGenetic VectorsHumansPromoter Regions, GeneticStaphylococcus aureusSwineTracheaVirus IntegrationCFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorDNA Transposable Elementsadeno-associated virusCFTRcystic fibrosisgene therapypiggyBac transposon

Identifiers

PMID31184507
PMCPMC6890402
OpenAlexW2949496696

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.