ArticleACS infectious diseases2019
Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in ACS infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Synthesis of 4-Aminoindole-Containing Cephalosporin Prodrugs and Their Biological Activity againstACS infectious diseases · 2026Article
- Targeting mycobacterial transpeptidases: evaluating the roles of Ldt and PBP inhibition in suppressingAntimicrobial agents and chemotherapy · 2025Article
- An Engineered Prodrug Selectively Suppresses β-Lactam-Resistant Bacteria in a Mixed Microbial Setting.ACS infectious diseases · 2025Article
- Metal-Catalyzed Cross-Coupling for the Synthesis of β-Lactam Drugs and Related Chemical Probes.ChemMedChem · 2025Review
- Article
- Cephem-Pyrazinoic Acid Conjugates: Circumventing Resistance in Mycobacterium tuberculosis.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Identification of β-Lactams Active againstACS infectious diseases · 2022Article
- Membrane Transporters Involved in the Antimicrobial Activities of Pyrithione inMolecules (Basel, Switzerland) · 2021Article
- The Odd Couple(s): An Overview of Beta-Lactam Antibiotics Bearing More Than One Pharmacophoric Group.International journal of molecular sciences · 2021Review
- A Multistress Model for High Throughput Screening Against Nonreplicating Mycobacterium tuberculosis.Methods in molecular biology (Clifton, N.J.) · 2021Article
- A Cephalosporin Prochelator Inhibits New Delhi Metallo-β-lactamase 1 without Removing Zinc.ACS infectious diseases · 2020Article
- Revisiting the β-Lactams for Tuberculosis Therapy with a Compound-Compound Synthetic Lethality Approach.Antimicrobial agents and chemotherapy · 2019Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
26 authors at 5 institutions in 3 countries.
Landys Lopez QuezadaDepartment of Microbiology and Immunology , Weill Cornell Medicine , 1300 York Avenue , New York , New York 10065 , United States.
Kelin LiDivision of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , 125 Mason Farm Road , Chapel Hill , North Carolina 27599 , United States.
Stacey L McDonaldDivision of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , 125 Mason Farm Road , Chapel Hill , North Carolina 27599 , United States.
Quyen NguyenDivision of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , 125 Mason Farm Road , Chapel Hill , North Carolina 27599 , United States.
Andrew J PerkowskiDivision of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , 125 Mason Farm Road , Chapel Hill , North Carolina 27599 , United States.
Cameron W PharrDivision of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , 125 Mason Farm Road , Chapel Hill , North Carolina 27599 , United States.
Ben GoldDepartment of Microbiology and Immunology , Weill Cornell Medicine , 1300 York Avenue , New York , New York 10065 , United States.ORCID 0000-0002-9562-8241
Julia RobertsDepartment of Microbiology and Immunology , Weill Cornell Medicine , 1300 York Avenue , New York , New York 10065 , United States.
Kathrine McAulayCenter for Global Health , Weill Cornell Medicine , 402 East 67th Street , New York , New York 10065 , United States.
Kohta SaitoDepartment of Medicine , Weill Cornell Medical College , New York , New York 10065 , United States.
Selin Somersan KarakayaDepartment of Medicine , Weill Cornell Medical College , New York , New York 10065 , United States.ORCID 0000-0003-2000-2700
Prisca Elis JavidniaDepartment of Medicine , Weill Cornell Medical College , New York , New York 10065 , United States.
Esther Porras de FranciscoDiseases of the Developing World (DDW), Tres Cantos Medicine Development Campus , GlaxoSmithKline , Severo Ochoa 2 , Tres Cantos , Madrid 28760 , Spain.
Manuel Marin AmievaDiseases of the Developing World (DDW), Tres Cantos Medicine Development Campus , GlaxoSmithKline , Severo Ochoa 2 , Tres Cantos , Madrid 28760 , Spain.
Sara Palomo Dı AzDiseases of the Developing World (DDW), Tres Cantos Medicine Development Campus , GlaxoSmithKline , Severo Ochoa 2 , Tres Cantos , Madrid 28760 , Spain.
Alfonso Mendoza LosanaDiseases of the Developing World (DDW), Tres Cantos Medicine Development Campus , GlaxoSmithKline , Severo Ochoa 2 , Tres Cantos , Madrid 28760 , Spain.
Matthew ZimmermanPublic Health Research Institute, New Jersey Medical School , Rutgers, the State University of New Jersey , 225 Warren Street , Newark , New Jersey 07013 , United States.
Hsin-Pin Ho LiangPublic Health Research Institute, New Jersey Medical School , Rutgers, the State University of New Jersey , 225 Warren Street , Newark , New Jersey 07013 , United States.
Jun ZhangDepartment of Microbiology and Immunology , Weill Cornell Medicine , 1300 York Avenue , New York , New York 10065 , United States.
Veronique DartoisPublic Health Research Institute, New Jersey Medical School , Rutgers, the State University of New Jersey , 225 Warren Street , Newark , New Jersey 07013 , United States.
Stéphanie SansEvotec ID (Lyon), SAS , 1541, Avenue Marcel Merieux , Marcy l'Etoile 69280 , France.
Sophie LagrangeEvotec ID (Lyon), SAS , 1541, Avenue Marcel Merieux , Marcy l'Etoile 69280 , France.
Laurent GoullieuxEvotec ID (Lyon), SAS , 1541, Avenue Marcel Merieux , Marcy l'Etoile 69280 , France.
Christine RoubertEvotec ID (Lyon), SAS , 1541, Avenue Marcel Merieux , Marcy l'Etoile 69280 , France.
Carl NathanDepartment of Microbiology and Immunology , Weill Cornell Medicine , 1300 York Avenue , New York , New York 10065 , United States.
Jeffrey AubéDivision of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , 125 Mason Farm Road , Chapel Hill , North Carolina 27599 , United States.ORCID 0000-0003-1049-5767
Cornell University · USUniversity of North Carolina at Chapel Hill · USEvotec (United States) · USGlaxoSmithKline (Spain) · ESRutgers, The State University of New Jersey · US
Funding
Viable but Nonculturable MtbU19AI111143 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI FITZGERALD, DANIEL W, GLICKMAN, MICHAEL S · 2014 to 2020
$48.6MA QTRAP 6500 LC-MS/MS System from SCIEX for high accuracy drug content analysisS10OD023524 · OD · RBHS-NEW JERSEY MEDICAL SCHOOL · PI DARTOIS, VERONIQUE · 2017 to 2017
$526kNIAID NIH HHS U19 AI111143NIH HHS S10 OD023524
Abstract
The historical view of β-lactams as ineffective antimycobacterials has given way to growing interest in the activity of this class against
Indexed as
DNA ReplicationAdministration, OralAnimalsAntitubercular AgentsCallithrixCephalosporinsDrug DiscoveryFemaleHep G2 CellsHigh-Throughput Screening AssaysHumansMiceMycobacterium tuberculosisPyridinesThionesAntitubercular AgentsCephalosporinsPyridinespyrithioneThionesantimycobacterialcephalosporinpyrithionetuberculosisβ-lactamase
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.