ArticleeLife2019
PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity.
Open access · goldAbstract read
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Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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66citing papers in PubMed
13.5field-weighted citation impact, top 1% of its field
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Who cites it
66 citing papers in PubMed, 95 citations in OpenAlex.
- Epigenome-wide Association Study Analysis of Calorie Restriction in Humans, CALERIETM Trial Analysis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Trial
- Plasma proteome profiling identifies XPNPEP3 as a novel biomarker associated with metabolic dysfunction-associated steatotic liver disease in patients with type 2 diabetes mellitus.Annals of medicine · 2026Article
- The protein disulfide isomerase P4HB/PDIA1 modulates cellular and misfolded forms of the prion protein.PLoS pathogens · 2026Article
- Molecular profiling of the single-cell proteome via gel electrophoresis and 3D single-molecule imaging.Nature communications · 2026Article
- PDIA1 promotes androgen receptor activation and prostate cancer cell survival through enhancing HMMR stability.FEBS letters · 2026Article
- DNA methylation marks associated with body composition in children from India and the Gambia: findings from the EMPHASIS study.Clinical epigenetics · 2026Article
- Coordinated expression and assembly of BiP, p58Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Polyadenylation of insulin mRNA by Tent5a regulates pancreatic beta cells.Nature communications · 2026Article
- Proinsulin regulators identified with CRISPR screen and in vivo mouse QTL mapping.Nature communications · 2026Article
- Resolving Single-Cell Gene Expression by Pseudotemporal Integration of Transcriptomic and Proteomic Datasets.Molecular & cellular proteomics : MCP · 2026Article
- Protein disulfide isomerases regulate androgen receptor stability and promote prostate cancer cell growth and survival.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A multichaperone condensate enhances protein folding in the endoplasmic reticulum.Nature cell biology · 2025Article
- Maturity-Onset Diabetes of the Young 10 (MODY10): A Comprehensive Review of Genetics, Clinical Features, and Therapeutic Advances.International journal of molecular sciences · 2025Review
- Quantification of Folded and Misfolded Proinsulin Forms Using Nonreducing SDS-PAGE and Proinsulin-Specific Immunoblotting.Bio-protocol · 2025Article
- The many connections of UFMylation with Alzheimer's disease: a comprehensive review.Molecular neurodegeneration · 2025Review
- Differential transport pathways of saturated and unsaturated fatty acid esters in male mouse hepatocytes.Nature communications · 2025Article
- Review
- Scars of oxidative stress: protein carbonylation and beta cell dysfunction in diabetes.Frontiers in endocrinology · 2025Review
- Molecular puzzle of insulin: structural assembly pathways and their role in diabetes.Frontiers in cell and developmental biology · 2025Review
- Exploring proinsulin proteostasis: insights into beta cell health and diabetes.Frontiers in molecular biosciences · 2025Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Insook JangDegenerative Diseases Program, SBP Medical Discovery Institute, La Jolla, United States.ORCID 0000-0001-7567-3849
Anita PottekatDegenerative Diseases Program, SBP Medical Discovery Institute, La Jolla, United States.
Juthakorn PoothongDegenerative Diseases Program, SBP Medical Discovery Institute, La Jolla, United States.
Jing YongDegenerative Diseases Program, SBP Medical Discovery Institute, La Jolla, United States.ORCID 0000-0002-4970-408X
Jacqueline Lagunas-AcostaDegenerative Diseases Program, SBP Medical Discovery Institute, La Jolla, United States.
Adriana CharbonoDegenerative Diseases Program, SBP Medical Discovery Institute, La Jolla, United States.
Zhouji ChenDegenerative Diseases Program, SBP Medical Discovery Institute, La Jolla, United States.
Donalyn L ScheunerDLS Consulting, Greenfield, United States.
Ming LiuDivision of Metabolism Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, United States.
Pamela Itkin-AnsariDepartment of Pediatrics, University of California, San Diego, San Diego, United States.
Peter ArvanDivision of Metabolism Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, United States.ORCID 0000-0002-4007-8799
Randal J KaufmanDegenerative Diseases Program, SBP Medical Discovery Institute, La Jolla, United States.ORCID 0000-0003-4277-316X
Discovery Institute · USUniversity of Michigan · USGreenfield Community College · USUniversity of California San Diego · US
Funding
Tumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael Jackson · 1985 to 2026
$107.2MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4MRegional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3MIntegrated Islet Distribution Program (U24) - 2021U24DK098085 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Carmella Evans-Molina, Joyce Carol Niland · 2021 to 2026
$17.8MProinsulin Trafficking for Insulin BiosynthesisR01DK048280 · NIDDK · YESHIVA UNIVERSITY · PI ARVAN, PETER · 1994 to 2024
$10.5MModifiers of Proinsulin Influence T2D SusceptibilityR24DK110973 · NIDDK · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ARVAN, PETER, ITKIN-ANSARI, PAMELA ROSE · 2016 to 2019
$4.1MHomeostatic Role of IRE1a-XBP1-PDI1 in Hepatic Lipid MetabolismR01DK103185 · NIDDK · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI KAUFMAN, RANDAL J. · 2015 to 2019
$2.9MMechanism of ER Protein Misfolding-Induced Mitochondrial DysfunctionR01DK113171 · NIDDK · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI KAUFMAN, RANDAL J. · 2017 to 2020
$2.5MNCI NIH HHS P30 CA030199NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK048280NIDDK NIH HHS R01 DK103185NIDDK NIH HHS R01 DK113171NIDDK NIH HHS R24 DK110973NIDDK NIH HHS U24 DK098085NIH HHS P30 CA030199NIH HHS P30 DK063491NIH HHS R01DK103185NIH HHS R01DK113171NIH HHS R24DK110973
Abstract
Regulated proinsulin biosynthesis, disulfide bond formation and ER redox homeostasis are essential to prevent Type two diabetes. In ß cells, protein disulfide isomerase A1 (PDIA1/
Indexed as
AnimalsDiabetes Mellitus, Type 2Diet, High-FatDisulfidesEndoplasmic ReticulumGlucose IntoleranceInsulinInsulin-Secreting CellsMice, KnockoutMice, TransgenicMitochondrial SwellingObesityOxidative StressProcollagen-Proline DioxygenaseProinsulinProtein Disulfide-IsomerasesDisulfidesInsulinP4hb protein, mouseProcollagen-Proline DioxygenaseProinsulinProtein Disulfide-Isomerasesbeta cell functioncell biologydisulfide bond formationglucose homeostasismousePDIA1proinsulin maturationtype 2 diabetes
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.