Evidence map›Paper›PMID 31183970›Full record

ArticleJournal of applied clinical medical physics2019

Treatment of cervical cancer with electronic brachytherapy.

Sergio Lozares-Cordero, José Antonio Font-Gómez, Almudena Gandía-Martínez, Anabela Miranda-Burgos, Agustina Méndez-Villamón, David Villa-Gazulla, Verónica Alba-Escorihuela, Sara Jiménez-Puertas, Víctor González-Pérez

Abstract read
In one paragraph

Article in Journal of applied clinical medical physics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Electronic brachytherapy for gynecological cancers - a systematic review.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sergio Lozares-CorderoDepartment of Physics and Radiation Protection, Miguel Servet University Hospital, Zaragoza, Spain.
José Antonio Font-GómezDepartment of Physics and Radiation Protection, Miguel Servet University Hospital, Zaragoza, Spain.
Almudena Gandía-MartínezDepartment of Physics and Radiation Protection, Miguel Servet University Hospital, Zaragoza, Spain.
Anabela Miranda-BurgosDepartment of Radiation Oncology, Miguel Servet University Hospital, Zaragoza, Spain.
Agustina Méndez-VillamónDepartment of Radiation Oncology, Miguel Servet University Hospital, Zaragoza, Spain.
David Villa-GazullaDepartment of Physics and Radiation Protection, Miguel Servet University Hospital, Zaragoza, Spain.
Verónica Alba-EscorihuelaDepartment of Physics and Radiation Protection, Miguel Servet University Hospital, Zaragoza, Spain.
Sara Jiménez-PuertasDepartment of Physics and Radiation Protection, Miguel Servet University Hospital, Zaragoza, Spain.
Víctor González-PérezDepartment of Physics and Radiation Protection, Fundación IVO, Valencia, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe report the first cervical cancer cases treated with interstitial electronic brachytherapy (eBT) at our hospital and compare them with plans made with high-dose-rate interstitial brachytherapy based on Ir192 (HDR-BT). MATERIALS AND

methodsEight patients with cervical cancer were treated with the Axxent eBT device (Xoft, Inc.). Planning was with magnetic resonance imaging and computed tomography following the recommendations of the EMBRACE protocol. The dosimetry parameters of organs at risk (OAR) were evaluated for the bladder, rectum, and sigmoid colon (D2cc, D1cc, and D0.1cc). In addition, the V150 and V200 of irradiated tissue were compared for both eBT and HDR-BT. All patients received intensity-modulated external beam radiation therapy with a regimen of 23 sessions of 2 Gy followed by four sessions of 7 Gy of eBT performed over 2 weeks (two sessions followed by another two sessions a week later) following the EMBRACE recommendations. Each of the eight patients was followed to assess acute toxicity associated with treatment.

resultsThe doses reaching OAR for eBT plans were lower than for HDR-BT plans. As for acute toxicity associated with eBT, very few cases of mucositis were detected. No cases of rectal toxicity and one case with grade 1 urinary toxicity were detected. The results at 1 month are equally good, and no relapses have occurred to date.

conclusionsThe first results of treatment with the Axxent eBT device are promising, as no recurrences have been observed and toxicity is very low. eBT is a good alternative for treating cervical cancer in centers without access to conventional HDR.

Indexed as

AdultAgedBrachytherapyElectronsFemaleHumansMiddle AgedNeoplasm Recurrence, LocalOrgans at RiskPrognosisRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRetrospective StudiesUterine Cervical Neoplasmscervical cancerelectronic brachytherapyHDRimage-guided brachytherapy

Identifiers

PMID31183970
PMCPMC6612687

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.