Evidence map›Paper›PMID 31183916›Full record

ReviewAdvanced materials (Deerfield Beach, Fla.)2020

Mitigation of Amyloidosis with Nanomaterials.

Pu Chun Ke, Emily H Pilkington, Yunxiang Sun, Ibrahim Javed, Aleksandr Kakinen, Guotao Peng, Feng Ding, Thomas P Davis

Abstract readReview
In one paragraph

Review in Advanced materials (Deerfield Beach, Fla.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Nanoplastics and Neurodegeneration: A Roadmap From Mechanism to Causation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Applications of Quantum Dots in Preventive Oncology.Asian Pacific journal of cancer prevention : APJCP · 2024
    Review
  12. Article
  13. Carbon nanotubes as neuroprotective agents.Exploration of neuroprotective therapy · 2024
    Article
  14. Review
  15. Direct Observation of Seeded Conformational Conversion of hIAPPJournal of chemical information and modeling · 2023
    Article
  16. Spike Protein Fragments Promote Alzheimer's Amyloidogenesis.ACS applied materials & interfaces · 2023
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pu Chun KeARC Center of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC, 3052, Australia.ORCID https://orcid.org/0000-0003-2134-0859
Emily H PilkingtonARC Center of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC, 3052, Australia.
Yunxiang SunDepartment of Physics and Astronomy, Clemson University, Clemson, SC, 29634, USA.
Ibrahim JavedARC Center of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC, 3052, Australia.
Aleksandr KakinenARC Center of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC, 3052, Australia.
Guotao PengInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, SE-17177, Sweden.
Feng DingDepartment of Physics and Astronomy, Clemson University, Clemson, SC, 29634, USA.
Thomas P DavisARC Center of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC, 3052, Australia.ORCID https://orcid.org/0000-0003-2581-4986

Funding

Inhibition of Human Islet Amyloid Polypeptide AggregationR35GM119691 · NIGMS · CLEMSON UNIVERSITY · PI DING, FENG · 2016 to 2020
$1.9M
AFTAM Research Collaboration AwardARC CE140100036National Science Foundation 1553945NIGMS NIH HHS R35 GM119691NIH HHS R35GM119691NIH MIRA R35GM119691NSFCAREERCBET 1553945
6 · The paper itself

Abstract

Amyloidosis is a biophysical phenomenon of protein aggregation with biological and pathogenic implications. Among the various strategies developed to date, nanomaterials and multifunctional nanocomposites possessing certain structural and physicochemical traits are promising candidates for mitigating amyloidosis in vitro and in vivo. The mechanisms underpinning protein aggregation and toxicity are introduced, and opportunities in materials science to drive this interdisciplinary field forward are highlighted. Advancement of this emerging frontier hinges on exploitation of protein self-assembly and interactions of amyloid proteins with nanoparticles, intracellular and extracellular proteins, chaperones, membranes, organelles, and biometals.

Indexed as

AmyloidosisAnimalsComputer SimulationHumansNanomedicineNanostructuresamyloidosisnanocompositesnanomaterialsoligomers

Identifiers

PMID31183916
PMCPMC6904546

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.