ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2019
Comparison of sex determination mechanism of germ cells between birds and fish: Cloning and expression analyses of chicken forkhead box L3-like gene.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 10 citations in OpenAlex.
- Short-term gonadal cultures are sufficient for germline transmission in a songbird.Stem cell reports · 2026Article
- Manipulating primordial germ cells from chicken and other bird species.The Journal of reproduction and development · 2026Review
- Strain-specific variations in the culture of chicken primordial germ cells.Scientific reports · 2025Article
- Review
- Prediction of sex-determination mechanisms in avian primordial germ cells using RNA-seq analysis.Scientific reports · 2022Article
- Comparison of sex determination mechanism of germ cells between birds and fish: Cloning and expression analyses of chicken forkhead box L3-like gene.Developmental dynamics : an official publication of the American Association of Anatomists · 2019Article
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4 authors at 1 institution in 1 country.
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Abstract
backgroundBirds harbor specific sex determination and differentiation mechanisms. Although the molecular mechanisms associated with sex determination in somatic cells have been elucidated, those for germ cells remain unclear.
resultsHere, we characterized the chicken forkhead box L3 (foxl3)-like gene as a sex-determination factor in sexually indifferent medaka germline stem cells. The foxl3-like gene was cloned by rapid amplification of cDNA ends, and the nucleotide sequence was analyzed. The deduced amino acid sequence was compared with FOXL3 sequences from other species, revealing low identity and similarity scores. Expression analysis of foxl3-like mRNA during gonadogenesis showed female left-gonad-specific temporal expression in an egg incubated from 10 to 16 days, as well as low general expression in certain hatched female chicken organs. Moreover, the amino acid sequence deduced for the FOXL3-like protein displayed low identity with medaka FOXL3, with the FOXL3-like protein specifically localized in the oogonia, whereas medaka FOXL3 was found in sexually indifferent germline stem cells. Furthermore, the timing of expression differed between the foxl3-like gene and that of medaka foxl3.
conclusionsThese results suggest that chicken FOXL3-like protein and medaka FOXL3 differ in terms of their functions as female sex-determination factors.
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