Evidence map›Paper›PMID 31183821›Full record

ReviewAdvances in experimental medicine and biology2019

Spontaneous Electrical Activity and Rhythmicity in Gastrointestinal Smooth Muscles.

Kenton M Sanders

Abstract readReview
In one paragraph

Review in Advances in experimental medicine and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
43.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 98 citations in OpenAlex.

  1. Article
  2. An update on pacemaking in the myometrium.The Journal of physiology · 2026
    Review
  3. Article
  4. The Functional Study of Prostaglandin EChonnam medical journal · 2026
    Article
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  19. Article
  20. International journal of medical sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Kenton M SandersDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA. ksanders@medicine.nevada.edu.
University of Nevada, Reno · US

Funding

Tissue, Cell and Tissue Culture CoreP01DK041315 · NIDDK · UNIVERSITY OF NEVADA RENO · PI KEEF, KATHLEEN D · 1989 to 2018
$26.3M
Single Cell Molecular ExpressionP30GM110767 · NIGMS · UNIVERSITY OF NEVADA RENO · PI SANDERS, KENTON M · 2014 to 2018
$5.4M
Electrical Control of Gastric MotilityR37DK040569 · NIDDK · UNIVERSITY OF NEVADA RENO · PI SANDERS, KENTON M · 2004 to 2013
$3.4M
Role of interstitial cells of Cajal in patterned colonic motor activityR01DK120759 · NIDDK · UNIVERSITY OF NEVADA RENO · PI Sal Baker, KENTON M SANDERS · 2019 to 2026
$3.4M
NIDDK NIH HHS P01 DK041315NIDDK NIH HHS R01 DK120759NIDDK NIH HHS R37 DK040569NIGMS NIH HHS P30 GM110767
6 · The paper itself

Abstract

The gastrointestinal (GI) tract has multifold tasks of ingesting, processing, and assimilating nutrients and disposing of wastes at appropriate times. These tasks are facilitated by several stereotypical motor patterns that build upon the intrinsic rhythmicity of the smooth muscles that generate phasic contractions in many regions of the gut. Phasic contractions result from a cyclical depolarization/repolarization cycle, known as electrical slow waves, which result from intrinsic pacemaker activity. Interstitial cells of Cajal (ICC) are electrically coupled to smooth muscle cells (SMCs) and generate and propagate pacemaker activity and slow waves. The mechanism of slow waves is dependent upon specialized conductances expressed by pacemaker ICC. The primary conductances responsible for slow waves in mice are Ano1, Ca

Indexed as

AnimalsAnoctamin-1Gastrointestinal MotilityGastrointestinal TractInterstitial Cells of CajalMiceMuscle, SmoothANO1 protein, mouseAnoctamin-1ANO1 channelsCa2+ transientElectrophysiologyGastrointestinal motilityInterstitial cells of CajalPacemakerSIP syncytiumSlow waveT-type Ca2+ channels

Identifiers

PMID31183821
PMCPMC7035145
OpenAlexW2950407573

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.