Evidence map›Paper›PMID 31183622›Full record

ArticleMikrochimica acta2019

A triple signal amplification method for chemiluminescent detection of the cancer marker microRNA-21.

Donghua Chen, Siming Wen, Rulin Peng, Qingsong Gong, Junjie Fei, Zhuo Fu, Chao Weng, Minna Liu

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Donghua ChenKey Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, 411105, Hunan, China. donghuachen@xtu.edu.cn.ORCID 0000-0002-4492-9642
Siming WenKey Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, 411105, Hunan, China.
Rulin PengKey Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, 411105, Hunan, China.
Qingsong GongKey Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, 411105, Hunan, China.
Junjie FeiKey Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, 411105, Hunan, China. fei_junjie@xtu.edu.cn.
Zhuo FuKey Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, 411105, Hunan, China.
Chao WengKey Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, 411105, Hunan, China.
Minna LiuKey Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, 411105, Hunan, China.
Xiangtan University · CN

Funding

Natural Science Foundation of Hunan Province 2019JJ50623The Scientific Research Fund of Hunan Provincial Education Department 15C1312
6 · The paper itself

Abstract

Mesoporous silica nanospheres (MSNs) are used in a triple signal amplification chemiluminescent (CL) assay for microRNA-21. It is based on (a) the synergistic amplification via loading and controlled-release of signal reagents by MSNs, (b) target recycling amplification, and (c) the enhancement effect of graphene oxide quantum dots (GOQD). CL is generated by the bis(2,4,6-trichlorophenyl) oxalate (TCPO) and H

Indexed as

Biomarkers, TumorBiosensing TechniquesDNA, Single-StrandedFluorescent DyesGraphiteHumansHydrogen PeroxideLimit of DetectionLuminescent MeasurementsMicroRNAsNanospheresNucleic Acid Amplification TechniquesNucleic Acid ConformationOxalatesQuantum DotsRhodaminesBiomarkers, Tumorbis(2,4,6-trichlorophenyl)oxalateDNA, Single-StrandedFluorescent Dyesgraphene oxideGraphiteHydrogen PeroxideMicroRNAsMIRN21 microRNA, humanOxalatesrhodamine BRhodaminesSilicon DioxideDuplex-specific nucleaseGraphene oxide quantum dotsLiquid biopsyMesoporous silica nanosphereRodamine B

Identifiers

PMID31183622
OpenAlexW2950896379

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.