Evidence map›Paper›PMID 31183513›Full record

ArticleHeart and vessels2019

Oral anticoagulant use and clinical outcomes in elderly Japanese patients: findings from the SAKURA AF Registry.

Toshihiko Nishida, Yasuo Okumura, Katsuaki Yokoyama, Naoya Matsumoto, Eizo Tachibana, Keiichiro Kuronuma, Koji Oiwa, Michiaki Matsumoto, Toshiaki Kojima, Shoji Hanada and 15 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Heart and vessels, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Review
  5. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 10 institutions in 1 country.

Toshihiko NishidaYokohama Chuo Hospital, Kanagawa, Japan.
Yasuo OkumuraDivision of Cardiology, Nihon University Itabashi Hospital, Tokyo, Japan. okumura.yasuo@nihon-u.ac.jp.
Katsuaki YokoyamaDepartment of Cardiology, Nihon University Hospital, Tokyo, Japan.
Naoya MatsumotoDepartment of Cardiology, Nihon University Hospital, Tokyo, Japan.
Eizo TachibanaKawaguchi Municipal Medical Center, Saitama, Japan.
Keiichiro KuronumaKawaguchi Municipal Medical Center, Saitama, Japan.
Koji OiwaYokohama Chuo Hospital, Kanagawa, Japan.
Michiaki MatsumotoYokohama Chuo Hospital, Kanagawa, Japan.
Toshiaki KojimaSekishindo Hospital, Saitama, Japan.
Shoji HanadaTMG Asakadai Medical Center, Saitama, Japan.
Kazumiki NomotoTokyo Rinkai Hospital, Tokyo, Japan.
Kazumasa SonodaTokyo Rinkai Hospital, Tokyo, Japan.
Ken ArimaKasukabe Medical Center, Saitama, Japan.
Rikitake KogawaKasukabe Medical Center, Saitama, Japan.
Fumiyuki TakahashiYasuda Hospital, Tokyo, Japan.
Tomobumi KotaniMakita General Hospital, Tokyo, Japan.
Kimie OhkuboItabashi Medical Association Hospital, Tokyo, Japan.
Seiji FukushimaUkima Central Hospital, Tokyo, Japan.
Satoru ItouItou Cardiovascular Clinic, Saitama, Japan.
Kunio KondoKondo Clinic, Tokyo, Japan.
Masaaki ChikuKeiai Clinic, Tokyo, Japan.
Yasumi OhnoOhno Medical Clinic, Tokyo, Japan.
Motoyuki OnikuraOnikura Clinic, Chiba, Japan.
Atsushi HirayamaDivision of Cardiology, Nihon University Itabashi Hospital, Tokyo, Japan.
SAKURA AF Registry Investigators
Gunma Chuo Hospital · JPNihon University · JPTokyo Rinkai Hospital · JPFukushimura Hospital · JPJapan Hospital Association · JPKeiai University · JPNoguchi Hospital · JPItochu (Japan) · JPNihon University Itabashi Hospital · JPOno Clinic · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Direct-acting oral anticoagulants (DOACs) are widely used in aged Japanese patients with atrial fibrillation (AF), but outcome data for such patients are limited. We compared outcomes between 1895 (58.5%) patients aged < 75 years (non-elderly), 1078 (33.3%) 75-84 years (elderly) and 264 (8.2%) ≥ 85 years (very elderly) enrolled in a prospective multicenter registry. Kaplan-Meier analysis (median follow-up: 39.3 months) revealed a significantly high incidence of stroke/systemic embolism (SE) among the very elderly relative to that among the non-elderly or elderly (3.2 vs. 1.2 and 1.5 events per 100 patient-years, p < 0.001). Major bleeding in the non-elderly group was significantly infrequent relative to that among the elderly or very elderly group (1.1 vs. 1.6 vs. 1.8 events, p = 0.033). After multivariate adjustment, the stroke/SE incidence was comparable between DOAC and warfarin users, regardless of age, but major bleeding decreased significantly among very elderly DOAC users (adjusted HR 0.220, 95% CI 0.042-0.920). The greater increasing incidence of stroke/SE than major bleeding as patients age suggests that stroke prevention should outweigh the bleeding risk when anticoagulants are being considered for aged patients. Our data indicated that DOACs can be a therapeutic option for stroke prevention in very elderly patients.

Indexed as

RegistriesAdministration, OralAdultAgedAged, 80 and overAnticoagulantsAtrial FibrillationDose-Response Relationship, DrugFactor Xa InhibitorsFemaleFollow-Up StudiesHumansIncidenceJapanMaleMiddle AgedAnticoagulantsFactor Xa InhibitorsWarfarinAgedAtrial fibrillationDirect oral anticoagulantWarfarin

Identifiers

PMID31183513
OpenAlexW2949704968

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.