ArticleTurkish journal of anaesthesiology and reanimation2019
Mannitol and the Combination of Mannitol and Gelatin Impair Whole Blood Coagulation and the Platelet Function
Article in Turkish journal of anaesthesiology and reanimation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- LC-MS-Based Serum Metabolomic Analysis Predicts the Risk of Tigecycline-Induced Coagulopathy in Critically Ill Patients.Drug design, development and therapy · 2025Observational
- Abnormal coagulation after hepatectomy in patients with normal preoperative coagulation function.BMC surgery · 2024Article
- Respective Contributions of Head and Extra-Head Injury Severities to the Occurrence of Early Coagulopathy Following Traumatic Brain Injury.Neurotrauma reportsArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMannitol 20% and succinylated gelatin 4% are routinely used in neurosurgical procedures. The aim of this
methodsBlood from 21 healthy volunteers was obtained and then diluted so as to form five groups: (1) 7% dilution with mannitol; (2) 10% dilution with gelatin; (3) 17% dilution with isotonic balanced electrolyte solution; (4) 17% dilution with mannitol+gelatin; and (5) undiluted blood. The extrinsic thrombelastometry (EXTEM) and fibrin thrombelastometry (FIBTEM) tests were examined by rotational thrombelastometry via ROTEM®, and thrombocyte aggregometry with the aspirin inhibiting- (ASPI), adenosine diphosphate- (ADP), and thrombin-activating protein (TRAP) tests performed by Multiplate.
resultsIn the EXTEM test clot formation time, the alpha angle, and maximum clot firmness were significantly reduced by mannitol and the combination of mannitol with gelatin. The platelet function tested in the ADP test was also significantly reduced with this combination.
conclusionIn this
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Registered trials
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