ArticleBJS open2019
Risk of needing completion thyroidectomy for low-risk papillary thyroid cancers treated by lobectomy.
Article in BJS open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Ablative Technologies for Thyroid Nodules: A Health Technology Assessment.Ontario health technology assessment series · 2026Pooled it
- Completion Thyroidectomy Trends and Rates: A Systematic Review and Meta-Analysis.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2025Pooled it
- Therapeutic Strategy in Low-Risk Papillary Thyroid Carcinoma - Long-Term Results of the First Single-Center Prospective Non-Randomized Trial Between 2011 and 2015.Frontiers in endocrinology · 2021Trial
- Impact of reflexive preoperative molecular testing for indeterminate nodules on lobectomy and completion thyroidectomy rates.European thyroid journal · 2026Article
- Risk of Cancer Recurrence Exerts the Strongest Influence on Choice Between Active Surveillance and Thyroid Surgery as Initial Treatment for Low-Risk Thyroid Cancer: Results of a Discrete Choice Experiment.World journal of surgery · 2025Article
- Article
- Beyond the Burn: Leukemia Threats Following Radioactive Iodine Ablation Therapy for Thyroid Cancer.Cancers · 2024Article
- Impact of fine-needle aspiration cytology in thyroidectomy extent and associated surgical morbidity in thyroid cancer.Langenbeck's archives of surgery · 2024Article
- How good is lobectomy for the Turkish population with papillary thyroid cancer? A clinicopathological evaluation.Turkish journal of surgery · 2023Article
- Characteristics ofCancers · 2023Article
- Current patterns of care in low-risk thyroid cancer-A national cross-sectional survey of Australian thyroid clinicians.Endocrinology, diabetes & metabolism · 2023Article
- Lobo-isthmectomy in the management of differentiated thyroid cancer.Thyroid research · 2023Review
- Comparison of surgical strategies in the treatment of low-risk differentiated thyroid cancer.BMC endocrine disorders · 2023Article
- Lobectomy and completion thyroidectomy rates increase after the 2015 American Thyroid Association Differentiated Thyroid Cancer Guidelines update.Endocrine oncology (Bristol, England) · 2023Article
- Optimal Cutoff Values of the Contact Angle of Tumor on Sonography System for Predicting Extrathyroidal Extension of Papillary Thyroid Carcinoma by Tumor Location.Clinical Medicine Insights. Oncology · 2023Article
- Molecular Testing for Thyroid Nodules: The Experience at McGill University Teaching Hospitals in Canada.Cancers · 2022Review
- Comparison between 2015 ATA guidelines and Italian Consensus for DTC management. A commented report.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2022Article
- Tumour volume is a predictor of lymphovascular invasion in differentiated small thyroid cancer.Endocrine oncology (Bristol, England) · 2022Article
- Does the Risk of Hypocalcemia Increase in Complementary Thyroidectomy Performed in Papillary Thyroid Cancer?Sisli Etfal Hastanesi tip bulteni · 2022Article
- Clinical Characteristics-Assisted Risk Stratification for Extent of Thyroidectomy in Patients With 1-4 cm Solitary Intrathyroidal Differentiated Thyroid Cancer.Frontiers in endocrinology · 2021Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Low-risk differentiated thyroid cancers may, according to the American Thyroid Association (ATA) 2015 guidelines, be managed initially with lobectomy. However, definitive risk categorization requires pathological assessment of the specimen, resulting in completion thyroidectomy being recommended when discordance between preoperative and postoperative staging occurs. This study sought to establish the expected rate of completion thyroidectomy in patients with papillary thyroid cancer (PTC) treated by lobectomy. Methods: Patients with PTC treated over 5 years (2013-2017 inclusive) and meeting the ATA criteria for lobectomy were identified from the prospectively developed database of a high-volume, university department of endocrine surgery. Concordance between the ATA initial and final recommendation, and the putative rate of completion thyroidectomy were calculated. Multivariable analysis was used to assess preoperative factors as predictors of the need for total thyroidectomy. Results: Of 275 patients with PTC who met ATA preoperative criteria for lobectomy there was concordance between this and the final recommendation in 158 (57·5 per cent) and discordance in 117 (43·5 per cent). Most common reasons for discordance were: angioinvasion (30·8 per cent), local invasion (23·9 per cent) or both (20·5 per cent). Four patients (1·5 per cent) had permanent hypoparathyroidism. On multivariable analysis, age, sex, tumour size and family history did not independently predict the final treatment required. Conclusion: Although many patients may be treated adequately with lobectomy, just under half would require completion thyroidectomy. Further work is needed on preoperative risk stratification but, before this, total thyroidectomy remains the treatment of choice for low-risk 1-4-cm PTC in the hands of high-volume thyroid surgeons who can demonstrate low complication rates.
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Registered trials
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