Evidence map›Paper›PMID 31183444›Full record

ArticleBJS open2019

Protocol for a multicentre randomized clinical trial comparing oncological outcomes of D2

A Karachun, A Petrov, L Panaiotti, Y Voschinin, T Ovchinnikova

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BJS open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03009227 (Study of Oncological Outcomes of D3 Lymph Node Dissection in Colon Cancer), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03009227 naunknown statusnot on this map

Study of Oncological Outcomes of D3 Lymph Node Dissection in Colon Cancer

TypeinterventionalSponsorN.N. Petrov National Medical Research Center of OncologyRan2017 to 2025Enrolled780ConditionsColonic Neoplasms MalignantArmsColonic resection with D2 lymph node dissection, Colonic resection with D3 lymph node dissection
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
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  12. The Mesentery in Complete Mesocolic Excision.Clinics in colon and rectal surgery · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

A KarachunSurgical Department of Abdominal Oncology National Medical Research Centre of Oncology named after N. N. Petrov St Petersburg Russia.
A PetrovSurgical Department of Abdominal Oncology National Medical Research Centre of Oncology named after N. N. Petrov St Petersburg Russia.ORCID 0000-0001-9630-9464
L PanaiottiSurgical Department of Abdominal Oncology National Medical Research Centre of Oncology named after N. N. Petrov St Petersburg Russia.
Y VoschininSurgical Department of Abdominal Oncology National Medical Research Centre of Oncology named after N. N. Petrov St Petersburg Russia.
T OvchinnikovaPathology Department National Medical Research Centre of Oncology named after N. N. Petrov St Petersburg Russia.
Institute of Oncology NN Petrov · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The extent of lymph node dissection in colonic cancer surgery remains arguable, and evidence from RCTs regarding extended lymph node dissection outcomes is lacking. This study aimed to compare the long-term results of D3 lymph node dissection with those of D2 dissection. Methods: This is a multicentre RCT. The aim is to enrol 768 patients with primary colonic cancer assigned randomly to D2 or D3 lymph node dissection. The trial is assessing the superiority of 5-year overall survival as the primary endpoint in patients undergoing D3 lymph node dissection Discussion: The results of this study will demonstrate whether extended lymph node dissection is superior to standard dissection in terms of oncological outcomes, and will also assess the impact of more extensive surgery on short-term outcomes and quality of life.

Indexed as

Colonic NeoplasmsLymph Node ExcisionMesocolonAftercareDisease-Free SurvivalEquivalence Trials as TopicFemaleHumansLymphatic MetastasisMaleMulticenter Studies as TopicNeoplasm StagingQuality of LifeRandomized Controlled Trials as TopicTreatment Outcome

Identifiers

PMID31183444
PMCPMC6551411
OpenAlexW2922354158

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.