Evidence map›Paper›PMID 31183418›Full record

ArticleHeliyon2019

Glucosamine/L-lactide copolymers as potential carriers for the development of a sustained rifampicin release system using

Jorge Ragusa, Daniela Gonzalez, Sumin Li, Sandra Noriega, Maciej Skotak, Gustavo Larsen

Open access · goldAbstract read
In one paragraph

Article in Heliyon, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jorge RagusaLNK Chemsolutions LLC, 4701 Innovation Drive, Lincoln, NE, 68521, USA.
Daniela GonzalezLNK Chemsolutions LLC, 4701 Innovation Drive, Lincoln, NE, 68521, USA.
Sumin LiLNK Chemsolutions LLC, 4701 Innovation Drive, Lincoln, NE, 68521, USA.
Sandra NoriegaLNK Chemsolutions LLC, 4701 Innovation Drive, Lincoln, NE, 68521, USA.
Maciej SkotakDepartment of Chemical and Biomolecular Engineering, University of Nebraska, Lincoln, NE, 68588-0643, USA.
Gustavo LarsenLNK Chemsolutions LLC, 4701 Innovation Drive, Lincoln, NE, 68521, USA.
LNKChemsolutions · USUniversity of Nebraska–Lincoln · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study aims at developing a new, ultrafine particle-based efficient antibiotic delivery system for the treatment of tuberculosis. The carrier material to make the rifampicin (RIF)-loaded particles is a low molecular weight star-shaped polymer produced from glucosamine (core building unit) and L-lactide (GluN-LLA). Particles were made via electrohydrodynamic atomization. Prolonged release (for up to 14 days) of RIF from these particles is reported. Drug release data fits the Korsmeyer-Peppas equation, which suggests the occurrence of a modified diffusion-controlled RIF release mechanism

Indexed as

MicrobiologyPharmaceutical chemistryPharmaceutical science

Identifiers

PMID31183418
PMCPMC6488545
OpenAlexW2942804183

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.