Evidence map›Paper›PMID 31183315›Full record

ArticleNanotheranostics2019

Ultrasound-mediated delivery of siESE complexed with microbubbles attenuates HER2+/- cell line proliferation and tumor growth in rodent models of breast cancer.

Kang-Ho Song, Tammy Trudeau, Adwitiya Kar, Mark A Borden, Arthur Gutierrez-Hartmann

Open access · goldAbstract read
In one paragraph

Article in Nanotheranostics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Ultrasound-targeted nucleic acid delivery for solid tumor therapy.Journal of controlled release : official journal of the Controlled Release Society · 2021
    Review
  8. Review
  9. Article
  10. DNA Nanostructures and DNA-Functionalized Nanoparticles for Cancer Theranostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Non-invasiveTheranostics · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kang-Ho SongDepartment of Mechanical Engineering, University of Colorado, Boulder, CO 80309, USA.
Tammy TrudeauDepartments of Medicine and of Biochemistry & Molecular Genetics, University of Colorado Anschutz Medical Center, Aurora, CO 80045, USA.
Adwitiya KarDepartments of Medicine and of Biochemistry & Molecular Genetics, University of Colorado Anschutz Medical Center, Aurora, CO 80045, USA.
Mark A BordenDepartment of Mechanical Engineering, University of Colorado, Boulder, CO 80309, USA.
Arthur Gutierrez-HartmannDepartments of Medicine and of Biochemistry & Molecular Genetics, University of Colorado Anschutz Medical Center, Aurora, CO 80045, USA.
University of Colorado Anschutz Medical Campus · USUniversity of Colorado Boulder · US

Funding

Ultrasound Molecular Imaging to Assess Therapeutic ResponseR01CA195051 · NCI · UNIVERSITY OF COLORADO · PI BORDEN, MARK ANDREW, DAYTON, PAUL A · 2015 to 2018
$2.0M
The Role of ESE-1 in HER2-Positive Breast CancerR01CA141201 · NCI · UNIVERSITY OF COLORADO DENVER · PI GUTIERREZ-HARTMANN, ARTHUR · 2011 to 2015
$1.5M
NCI NIH HHS R01 CA141201NCI NIH HHS R01 CA195051
6 · The paper itself

Abstract

The highly tunable, noninvasive and spatially targeted nature of microbubble-enhanced, ultrasound-guided (MB+US) drug delivery makes it desirable for a wide variety of therapies. In breast cancer, both HER2

Indexed as

Breast NeoplasmsMicrobubblesUltrasonic WavesAnimalsCell Line, TumorErb-b2 Receptor Tyrosine KinasesFemaleHumansMiceMice, Inbred NODMice, SCIDTrastuzumabXenograft Model Antitumor AssaysERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesTrastuzumabESE-1gene therapymicrobubblestheranosticsultrasound contrast agent

Identifiers

PMID31183315
PMCPMC6536781
OpenAlexW2947634788

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.