ArticleJournal of gastrointestinal oncology2019
Mucinous adenocarcinoma arising from chronic perianal fistula-a multidisciplinary approach.
Article in Journal of gastrointestinal oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Perianal Mucinous Adenocarcinoma: A Case Report and a Systematic Review of the Literature.Journal of gastrointestinal cancer · 2024Pooled it
- Non-mucinous adenocarcinomas and squamous cell carcinomas of the anal region masquerading as abscess or fistula: a retrospective analysis and systematic review of literature.Journal of cancer research and clinical oncology · 2022Pooled it
- Complete pathological response to neoadjuvant chemoradiotherapy in Crohn's disease-associated fistula adenocarcinoma: a case report.Frontiers in medicine · 2026Article
- Metastatic Anal Fistula Carcinoma after Rectosigmoid Cancer Surgery Treated with Robot-Assisted Abdominoperineal Resection and Gluteal Myocutaneous Flap Reconstruction: A Case Report.Surgical case reports · 2026Article
- Surgical management of mucinous adenocarcinoma arising in perianal fistula: A case series.Surgery open science · 2025Article
- "Budding"-an early MRI feature established in a case-control study of perianal fistula mucinous adenocarcinoma.Journal of gastrointestinal oncology · 2025Article
- Mucinous Adenocarcinoma Arising from Perianal Fistula.Indian journal of surgical oncology · 2024Article
- Laparoscopic abdominoperineal resection and myocutaneous flap reconstruction for anal fistula cancer arising from complicated anal fistula: two case reports.Surgical case reports · 2024Article
- Chronic fistula in ano associated with adenocarcinoma: a case report with a review of the literature.Annals of coloproctology · 2024Article
- Article
- Beyond squamous cell carcinoma: MRI appearance of uncommon anal neoplasms and mimickers.Abdominal radiology (New York) · 2023Review
- Adjuvant chemoradiotherapy does not improve outcomes in patients with fistula-associated anal adenocarcinoma undergoing abdominoperineal resection.Frontiers in oncology · 2022Article
- Unusual Presentation of Carcinoma Rectum-a Case Report.Indian journal of surgical oncology · 2021Article
- Pattern of distant metastases and predictive nomograms in colorectal mucinous adenocarcinoma: a SEER analysis.Journal of gastrointestinal oncology · 2021Article
- Journey through Crohn's Disease Complication: From Fistula Formation to Future Therapies.Journal of clinical medicine · 2021Review
- Article
- Perianal Inflammation or Something More?Journal of clinical imaging science · 2021Article
- Mucinous adenocarcinoma of the buttock associated with hidradenitis: A case report.World journal of clinical cases · 2020Article
- Review
- Incidental discovery of mucinous adenocarcinoma from a suspected inflammatory perianal mass.Journal of surgical case reports · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mucinous adenocarcinoma (MA) is a rare entity. Indeed, the pathogenesis of fistula-associated perianal MA is still controversial. Due to the lack of informed evidence regarding this malignancy, no guidelines have been established concerning diagnostic and treatment strategies. The aim of this article is to report our experience and outcomes after three cases of large perianal MA treated in our center. From our retrospective chart review, we identified three male patients with chronic perianal fistula-in-ano who progressively developed perianal MA, confirmed by pelvic magnetic resonance (MRI) and histopathological examination performed on biopsy. We hereby, in accordance with the Surgical CAse REport (SCARE) guidelines, describe the management and further follow-up of each patient. The three patients underwent preoperative chemoradiation therapy, followed by ischioanal abdominoperineal resection (APR). Perineal reconstruction was needed in every case, using a vertical rectus abdominis myocutaneous (VRAM) flap and, punctually, a left fasciocutaneous flap was used too. Also, two of three patients completed the treatment with adjuvant chemotherapy. Neither recurrences nor distant metastases have been observed during the follow-up in both cases that finished the multimodal treatment. MA arising from chronic perianal fistula has an indolent growth with locoregional aggressiveness and a high risk of local recurrence. Therefore, although an ischioanal APR remains the surgical treatment of choice, an aggressive multimodal approach combining preoperative chemoradiation and adjuvant chemotherapy may achieve favorable effectiveness and promising response rates.
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