Evidence map›Paper›PMID 31183088›Full record

ArticleClinical case reports2019

Light chain lambda myeloma with fatal AL cardiac amyloidosis in a 21-year-old patient: A case report and review.

Vincent Camus, Sydney Dubois, Pierre-Alain Thiébaut, Stéphane Lepretre, Pascal Lenain, Jean-Michel Picquenot, Elena-Liana Veresezan, Arnaud François, Dominique Penther, Fabrice Bauer and 2 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Clinical case reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Vincent CamusInserm U1245 and Department of Hematology Centre Henri Becquerel and Normandie Univ UNIROUEN Rouen France.ORCID https://orcid.org/0000-0002-1559-007X
Sydney DuboisDepartment of Internal Medicine Charles Nicolle University Hospital Rouen France.
Pierre-Alain ThiébautDepartment of Pathology Charles Nicolle University Hospital Rouen France.
Stéphane LepretreInserm U1245 and Department of Hematology Centre Henri Becquerel and Normandie Univ UNIROUEN Rouen France.
Pascal LenainInserm U1245 and Department of Hematology Centre Henri Becquerel and Normandie Univ UNIROUEN Rouen France.
Jean-Michel PicquenotDepartment of Pathology Centre Henri Becquerel Rouen France.
Elena-Liana VeresezanDepartment of Pathology Centre Henri Becquerel Rouen France.
Arnaud FrançoisDepartment of Pathology Charles Nicolle University Hospital Rouen France.
Dominique PentherDepartment of Genetic Oncology Centre Henri Becquerel Rouen France.
Fabrice BauerDepartment of Cardiology Charles Nicolle University Hospital Rouen France.
Arnaud JaccardCentre national de référence de l'amylose AL et des autres maladies par dépôt d'immunoglobulines monoclonales hôpital Dupuytren, CHU de Limoges Limoges cedex France.
Fabrice JardinInserm U1245 and Department of Hematology Centre Henri Becquerel and Normandie Univ UNIROUEN Rouen France.
Hôpital Charles-Nicolle · FRInserm · FRCentre Henri BecquerelCentre Hospitalier Universitaire de Limoges · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multi-organ AL amyloidosis is a therapeutic challenge because of light chain deposits severely damaging the function of concerned organs. Cardiac involvement, which leads to concentric hypertrophy of both ventricles, is particularly severe and leads to poor prognosis regardless of combination chemotherapy. This case pinpoints the relevance of combining clinical, histological, and echocardiographic information in the management of this complex and life-threatening disease.

Indexed as

cardiac involvementchemotherapydaratumumablight chain myelomamulti‐organ amyloidosis

Identifiers

PMID31183088
PMCPMC6552948
OpenAlexW2944395624

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.