ArticleChemical science2019
Synthesis of α-heterosubstituted ketones through sulfur mediated difunctionalization of internal alkynes.
Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 44 citations in OpenAlex.
- Synthese von α-Aminosäurederivaten durch hydrative Aminierung von Alkinen.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2023Article
- Direct Synthesis of α-Amino Acid Derivatives by Hydrative Amination of Alkynes.Angewandte Chemie (International ed. in English) · 2023Article
- Metal-free catalytic hydrocarboxylation of hexafluorobut-2-yne.RSC advances · 2021Article
- Organocatalytic asymmetric synthesis of α-amino esters from sulfoxonium ylides.Chemical science · 2021Article
- Palladium-catalyzed benzylic C(spChemical science · 2021Article
- Selective synthesis of α-organylthio esters and α-organylthio ketones from β-keto esters and sodiumBeilstein journal of organic chemistry · 2021Article
- Trifluoromethyl Sulfoxides: Reagents for Metal-Free C-H Trifluoromethylthiolation.Angewandte Chemie (International ed. in English) · 2020Article
- Sulfoxide-mediated oxidative cross-coupling of phenols.Chemical science · 2020Article
- Synthesis of γ-substituted carbonyl compounds from DMSO-mediated oxidation of enynamides: mechanistic insights and carbon- and hetero-functionalizations.Chemical science · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synthesis of α-heterosubstituted ketones was achieved through sulfur mediated difunctionalization of internal alkynes in one pot. The reaction design involves: phenyl substituted internal alkyne attacking triflic anhydride activated diphenyl sulfoxide to give a sulfonium vinyl triflate intermediate, hydrolysis to give an α-sulfonium ketone, and then substitution with various nucleophiles. This method provides a unified route to access α-amino ketones, α-acyloxy ketones, α-thio ketones, α-halo ketones, α-hydroxy ketones, and related heterocyclic structures, in a rapid fashion.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.