ArticlePain research & management2019
Microglial BDNF, PI3K, and p-ERK in the Spinal Cord Are Suppressed by Pulsed Radiofrequency on Dorsal Root Ganglion to Ease SNI-Induced Neuropathic Pain in Rats.
Article in Pain research & management, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Comparison of two distinct needle tip positions in pulsed radiofrequency for herpes zoster-related pain.CNS neuroscience & therapeutics · 2023Trial
- Neuroplasticity-Driven Mechanisms and Therapeutic Targets in the Anterior Cingulate Cortex in Neuropathic Pain.Brain and behavior · 2026Review
- [Safety and efficacy of pulsed radiofrequency therapy for zoster-associated trigeminal neuralgia under general anesthesia].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Pulsed Radiofrequency and Epigenetic Modulation of Pain Pathways: A Systematic Review Based on Preclinical Evidence.Journal of pain research · 2026Review
- Optogenetic stimulation attenuates central post-stroke pain via BDNF/TrkB signaling pathway modulation in the ascending pain modulation system.Scientific reports · 2025Article
- Elucidation of the treatment mechanism of pulsed radiofrequency based on its antiinflammatory effects.Scientific reports · 2025Article
- Pulsed Radiofrequency for Lumbosacral Radicular Pain in Dogs: Description and Assessment of an Ultrasound- and Fluoroscopy-Guided Technique in a Cadaveric Model.Animals : an open access journal from MDPI · 2025Article
- Interventional pain management in dogs with lumbosacral stenosis: preliminary long-term clinical outcomes of combined foraminal and epidural injections with or without pulsed radiofrequency.Frontiers in veterinary science · 2025Article
- Efficacy of pulsed radiofrequency stimulation in patients with chronic pain: a narrative review.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- Dorsal Root Ganglion Pulsed Radiofrequency with Scar Radiofrequency Ablation Combined for Chronic Postoperative Abdominal Pain: A Retrospective Study.Journal of pain research · 2025Article
- Advances in Neuropathic Pain Research: Selected Intracellular Factors as Potential Targets for Multidirectional Analgesics.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Review
- Methyl Ferulic Acid Alleviates Neuropathic Pain by Inhibiting Nox4-induced Ferroptosis in Dorsal Root Ganglia Neurons in Rats.Molecular neurobiology · 2023Article
- Pulsed Radiofrequency Decreases pERK and Affects Intracellular CaJournal of pain research · 2023Article
- Pulsed Radiofrequency 2 Hz Preserves the Dorsal Root Ganglion Neuron Physiological CaJournal of pain research · 2023Article
- CCR1 enhances SUMOylation of DGCR8 by up-regulating ERK phosphorylation to promote spinal nerve ligation-induced neuropathic pain.Gene therapy · 2022Article
- [ANA- 12 inhibits spinal inflammation and alleviates acute and chronic pain in rats by targeted blocking of BDNF/TrkB signaling].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- Effects of subanesthetic intravenous ketamine infusion on neuroplasticity-related proteins in male and female Sprague-Dawley rats.IBRO neuroscience reports · 2021Article
- Therapeutic effects of peripherally administrated neural crest stem cells on pain and spinal cord changes after sciatic nerve transection.Stem cell research & therapy · 2021Article
- LIFU Alleviates Neuropathic Pain by Improving the KCCNeural plasticity · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Pulsed radiofrequency (PRF) on the dorsal root ganglion (DRG) has been applied to alleviate neuropathic pain effectively, yet the mechanisms underlying pain reduction owing to this treatment are not clarified completely. The activated microglia, brain-derived neurotrophic factor (BDNF), phosphatidylinositol 3-kinase (PI3K), and phosphorylated extracellular signal-regulated kinase (p-ERK) in the spinal cord were demonstrated to be involved in developing neuropathic pain. Also, it has been just known that PRF on DRG inhibits the microglial activation in nerve injury rats. Here, we aim to investigate whether PRF treatment could regulate the levels of BDNF, PI3K, and p-ERK in the spinal cord of rats with spared nerve injury (SNI) via suppressing the spinal microglia activation to ease neuropathic pain. Methods: The rats with SNI were intrathecally treated with minocycline (specific microglia inhibitor) or same volume of dimethyl sulfoxide once daily, beginning from 1 h before nerve transection to 7 days. PRF was applied adjacent to the L Results: The paw withdrawal mechanical threshold and paw withdrawal thermal latency decreased in the ipsilateral hind paws after SNI, and the spinal levels of Iba1, BDNF, PI3K, and p-ERK increased on day 21 after SNI compared with baseline ( Conclusion: Microglial BDNF, PI3K, and p-ERK in the spinal cord are suppressed by the therapy of PRF on DRG to ease SNI-induced neuropathic pain in rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.