ArticleMediators of inflammation2019
Effects of SHINBARO2 on Rat Models of Lumbar Spinal Stenosis.
Article in Mediators of inflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Pragmatic Randomized Controlled Trial of Pharmacopuncture Therapy for Cervical Disc Herniation: A Pilot Study.Journal of pain research · 2025Trial
- A Pragmatic Randomized Controlled Trial on the Effectiveness and Safety of Pharmacopuncture for Chronic Lower Back Pain.Journal of pain research · 2023Trial
- Integrative Korean Medicine Treatment Including Ultrasound-Guided Shinbaro 2 Pharmacopuncture and Motion-Style Acupuncture Treatment for Acute Lumbar Disc Herniation with Foot Drop: A Case Report.Healthcare (Basel, Switzerland) · 2026Article
- Pharmacopuncture therapy versus usual care for lumbar spinal stenosis: A randomized controlled trial.Integrative medicine research · 2026Article
- Animal Models of Intervertebral Disc Diseases: Advantages, Limitations, and Future Directions.Neurology international · 2024Review
- Pharmacopuncture therapy for adhesive capsulitis: A pragmatic randomized controlled pilot study.Integrative medicine research · 2024Article
- Integrative Medicine Focusing on Ultrasound-Guided High-Dose Shinbaro 2 Pharmacopuncture for Acute Herniated Intervertebral Discs: A Case Report.Healthcare (Basel, Switzerland) · 2024Article
- Effect of human umbilical cord blood-mesenchymal stem cells on cisplatin-induced nephrotoxicity in rats.Molecular biology reports · 2024Article
- Repeated epidural delivery of Shinbaro2: effects on neural recovery, inflammation, and pain modulation in a rat model of lumbar spinal stenosis.Frontiers in pharmacology · 2024Article
- Modulation of the biological network of lumbar spinal stenosis by Tongdu Huoxue Decoction based on clinical metabolomics.Frontiers in molecular biosciences · 2023Article
- Effects of the administration of Shinbaro 2 in a rat lumbar disk herniation model.Frontiers in neurology · 2023Article
- A Comparative Study of the Effectiveness of Pharmacopuncture Therapy for Chronic Neck Pain: A Pragmatic, Randomized, Controlled Trial.Journal of clinical medicine · 2021Article
- Evaluation of the effects of differences in silicone hardness on rat model of lumbar spinal stenosis.PloS one · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lumbar spinal stenosis (LSS) is a major cause of chronic low back pain; however, only a few therapies which have been used in clinics still have limited effects on functional recovery. SHINBARO2 is a refined traditional formulation for inflamed lesions and relieve pain of muscular skeletal disease. This study aimed at investigating the effects of SHINBARO2 on LSS and at determining its underlying molecular mechanism in rat models. The LSS rat models were set up by surgical operations in 6-week-old male Sprague-Dawley rats. SHINBARO2 was orally or intraperitoneally administered for 14 days. The motor and sensory ability of rats were evaluated using the activity cage and hot plate method. On the termination day, total vertebrae including the disc and spinal cord were excised for ex vivo study. SHINBARO2 improved locomotor functions and pain sensitivity in LSS rat models. Mechanism study suggested that SHINBARO2 inhibited the production of nitric oxide and prostaglandin E
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