Evidence map›Paper›PMID 31182890›Full record

ArticleIranian journal of medical sciences2019

Impact of the Polymorphism of the

Elena Yu Bragina, Nadezhda P Babushkina, Anna F Garaeva, Alexey A Rudko, Dmitry Yu Tsitrikov, Densema E Gomboeva, Maxim B Freidin

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Iranian journal of medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. CLEC4E (Mincle) genetic variation associates with pulmonary tuberculosis in Guinea-Bissau (West Africa).Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2020
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Elena Yu BraginaResearch Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia.
Nadezhda P BabushkinaResearch Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia.
Anna F GaraevaResearch Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia.
Alexey A RudkoResearch Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia.
Dmitry Yu TsitrikovResearch Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia.
Densema E GomboevaResearch Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia.
Maxim B FreidinResearch Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia.
Research Institute of Medical Genetics of Russian Academy of Medical Sciences · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTuberculosis (TB) is one of the most significant health-care problems worldwide. The host's genetics play an important role in the development of TB in humans. The disease progresses through several stages, each of which can be under the control of different genes. The precise genes influencing the different stages of the disease are not yet identified. The aim of the current study was to determine the associations between primary and secondary TB and the polymorphisms of novel candidate genes for TB susceptibility, namely

methodsA total of 357 patients with TB (130 cases with primary TB and 227 cases with secondary TB) from the Siberian region of Russia as well as 445 healthy controls were studied. The study was performed at the Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia, between July 2015 and November 2016. Genotyping was carried out using MALDI-TOF mass spectrometry and PCR-RFLP. The associations between the single-nucleotide polymorphisms and TB were assessed using logistic regression adjusting for covariates (age and gender). Multiple testing was addressed via the experiment-wise permutation approach. The statistical significance threshold was a P value less than 0.05 for the permutation P values. The analyses were done in R 3.2 statistical software.

resultsAn association was established between the rs1880661 variant of the

conclusionThe results suggested that the

Indexed as

Polymorphism, geneticPolymorphism, single nucleotideTuberculosis

Identifiers

PMID31182890
PMCPMC6525733
OpenAlexW2915999716

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.