ArticleNature neuroscience2019
State-dependent decoupling of sensory and motor circuits underlies behavioral flexibility in Drosophila.
Article in Nature neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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57 citing papers in PubMed.
- Sticking the landing: leg mechanosensory feedback coordinates the transition from flight to landing.bioRxiv : the preprint server for biology · 2026Article
- Hoverfly responses to looming stimuli depend on elevation and speed.The Journal of experimental biology · 2026Article
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- Drosophila DNp03 descending neurons serve as a hub within a flight saccade network.Current biology : CB · 2026Article
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- Feeding state-dependent neuropeptidergic modulation of reciprocally interconnected inhibitory neurons biases sensorimotor decisions in Drosophila.Nature communications · 2025Article
- Caterpillars suppress nocifensive behaviours during the quiescent 'sphinx' state.Biology letters · 2025Article
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- The visuomotor transformations underlying target-directed behavior.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
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- Neural circuits underlying context-dependent competition between defensive actions in Drosophila larvae.Nature communications · 2025Article
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- Divergent visual ecology of Drosophila species drives object-tracking strategies matched to landscape sparsity.Current biology : CB · 2024Article
- Insect Flight: State of the Field and Future Directions.Integrative and comparative biology · 2024Article
- Comparative connectomics of the descending and ascending neurons of thebioRxiv : the preprint server for biology · 2024Article
- Article
- Social state gates vision using three circuit mechanisms inbioRxiv : the preprint server for biology · 2024Article
- Organization of an ascending circuit that conveys flight motor state in Drosophila.Current biology : CB · 2024Article
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Abstract
An approaching predator and self-motion toward an object can generate similar looming patterns on the retina, but these situations demand different rapid responses. How central circuits flexibly process visual cues to activate appropriate, fast motor pathways remains unclear. Here we identify two descending neuron (DN) types that control landing and contribute to visuomotor flexibility in Drosophila. For each, silencing impairs visually evoked landing, activation drives landing, and spike rate determines leg extension amplitude. Critically, visual responses of both DNs are severely attenuated during non-flight periods, effectively decoupling visual stimuli from the landing motor pathway when landing is inappropriate. The flight-dependence mechanism differs between DN types. Octopamine exposure mimics flight effects in one, whereas the other probably receives neuronal feedback from flight motor circuits. Thus, this sensorimotor flexibility arises from distinct mechanisms for gating action-specific descending pathways, such that sensory and motor networks are coupled or decoupled according to the behavioral state.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.