ArticleNature neuroscience2019
Circuit mechanisms for the maintenance and manipulation of information in working memory.
Article in Nature neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.
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Who cites it
100 citing papers in PubMed.
- Article
- Neural dynamics underlying minute-timescale persistent behaviour in the human brain.Nature human behaviour · 2026Article
- Working Memory Impairment Induced by Chemotherapy-A Narrative Review.Brain sciences · 2026Review
- A computational theory of short-term synaptic plasticity: synapses learn to tell time.Research square · 2026Article
- Trajectories of Response Inhibition Development in Adolescence.bioRxiv : the preprint server for biology · 2026Article
- The cost of efficiency in flexible neural representations.bioRxiv : the preprint server for biology · 2026Article
- Multiplexed changes in synaptic transmission underlie stress-induced reduction of persistent firing in the parietal cortex.Progress in neurobiology · 2026Article
- Flexible goal learning involves coordinated population activity in dCA1 and medial orbitofrontal cortex.PLoS biology · 2026Article
- Intrinsic persistent firing in CA1 encodes elapsed time across behaviorally relevant scales.bioRxiv : the preprint server for biology · 2025Article
- Disinhibition of a recurrent attractor gates a persistent goal signal for navigation.bioRxiv : the preprint server for biology · 2025Article
- Nonlinear feedback modulation contributes to the optimization of flexible decision-making.eLife · 2025Article
- Network dynamics underlying activity-timescale differences between cortical regions.bioRxiv : the preprint server for biology · 2025Article
- Cerebellar and subcortical contributions to working memory manipulation.Communications biology · 2025Article
- Serial dependence in face-gender classification revealed in low-beta frequency EEG.BMC biology · 2025Article
- Stimulus representation in human frontal cortex supports flexible control in working memory.eLife · 2025Article
- Phase of firing does not reflect temporal order in sequence memory of humans and recurrent neural networks.Nature neuroscience · 2025Article
- Mixed recurrent connectivity in primate prefrontal cortex.PLoS computational biology · 2025Article
- Recurrent neural networks with transient trajectory explain working memory encoding mechanisms.Communications biology · 2025Article
- Article
- Single-unit activations confer inductive biases for emergent circuit solutions to cognitive tasks.Nature machine intelligence · 2025Article
40 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
Recently it has been proposed that information in working memory (WM) may not always be stored in persistent neuronal activity but can be maintained in 'activity-silent' hidden states, such as synaptic efficacies endowed with short-term synaptic plasticity. To test this idea computationally, we investigated recurrent neural network models trained to perform several WM-dependent tasks, in which WM representation emerges from learning and is not a priori assumed to depend on self-sustained persistent activity. We found that short-term synaptic plasticity can support the short-term maintenance of information, provided that the memory delay period is sufficiently short. However, in tasks that require actively manipulating information, persistent activity naturally emerges from learning, and the amount of persistent activity scales with the degree of manipulation required. These results shed insight into the current debate on WM encoding and suggest that persistent activity can vary markedly between short-term memory tasks with different cognitive demands.
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