ArticleNature genetics2019
A deletion mutation in TaHRC confers Fhb1 resistance to Fusarium head blight in wheat.
Article in Nature genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 179 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
179 citing papers in PubMed, 2 syntheses or guidelines pooled it, 411 citations in OpenAlex.
- Priority actions for Fusarium head blight resistance in durum wheat: Insights from the wheat initiative.The plant genome · 2025Pooled it
- Epigenomics as Potential Tools for Enhancing Magnitude of Breeding Approaches for Developing Climate Resilient Chickpea.Frontiers in genetics · 2022Pooled it
- A conserved fungal Egh16-like effector suppresses host defense by disrupting ATP binding of wheat MPK3.Journal of integrative plant biology · 2026Article
- Chromosome-scale assembly of wheat cultivar Sumai 3, a major germplasm source for Fusarium head blight resistance.The plant genome · 2026Article
- Epigenetic regulation of TaFIP phytocytokine clusters confers basal resistance via receptor kinase TaFIPR in wheat.Nature plants · 2026Article
- Targeted editing of TaROD1 confers disease resistance to both Fusarium head blight and powdery mildew in wheat without growth penalty.Plant communications · 2026Article
- Genome-wide association mapping of native QTLs for Fusarium head blight resistance in US winter wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Identification and comprehensive characterization of the OVATE family protein in litchi.BMC plant biology · 2026Article
- Development of Wheat Lines Pyramiding the Fusarium Head Blight Resistance GenePlants (Basel, Switzerland) · 2026Article
- Dissection of Fusarium head blight resistance in a modified nested association mapping panel of synthetic and bread wheat germplasm.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Compartmentalised Function of TaHRC-R Orchestrates ROS Production and Nuclear Condensate Dynamics.Molecular plant pathology · 2026Article
- Endophytic fungi as sustainable tools for Fusarium head blight control in cereals: mechanisms, applications and limitations.Frontiers in plant science · 2026Review
- Uncovering yield-related traits loci in Chinese wheat landraces using GWAS.Frontiers in plant science · 2026Article
- Pre-breeding to establishFrontiers in plant science · 2026Article
- Chromosomal deletions in banana somaclonal variants reveal negative regulators of immunity underlyingProceedings of the National Academy of Sciences of the United States of America · 2025Article
- FHBDSR-Net: automated measurement of diseased spikelet rate of Fusarium Head Blight on wheat spikes.aBIOTECH · 2025Article
- Genetic mapping of the Fusarium head blight resistance gene in wheat Guixie 3.Journal of applied genetics · 2025Article
- Analysis of a Series of Mutants Highlights Complex Regulation of Fusarium Head Blight Resistance Conferred by Fhb1 Locus in Wheat.Plant biotechnology journal · 2025Article
- An ABF5b-HsfA2h/HsfC2a-NCED2b/POD4/HSP26 module integrates multiple signaling pathway to modulate heat stress tolerance in wheat.Plant biotechnology journal · 2025Article
- The Enhancement of Fungal Disease Resistance in Major Staple Crops Using CRISPR-Cas Technology.Genes · 2025Review
119 more citing papers are in PubMed but not listed here.
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15 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fusarium head blight (FHB), which is mainly caused by Fusarium graminearum, is a destructive wheat disease that threatens global wheat production. Fhb1, a quantitative trait locus discovered in Chinese germplasm, provides the most stable and the largest effect on FHB resistance in wheat. Here we show that TaHRC, a gene that encodes a putative histidine-rich calcium-binding protein, is the key determinant of Fhb1-mediated resistance to FHB. We demonstrate that TaHRC encodes a nuclear protein conferring FHB susceptibility and that a deletion spanning the start codon of this gene results in FHB resistance. Identical sequences of the TaHRC-R allele in diverse accessions indicate that Fhb1 had a single origin, and phylogenetic and haplotype analyses suggest that the TaHRC-R allele most likely originated from a line carrying the Dahongpao haplotype. This discovery opens a new avenue to improve FHB resistance in wheat, and possibly in other cereal crops, by manipulating TaHRC sequence through bioengineering approaches.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.