Evidence map›Paper›PMID 31182790›Full record

ArticleScientific reports2019

IκBζ facilitates protective immunity against Salmonella infection via Th1 differentiation and IgG production.

Jae-Hee Ahn, Jaewon Cho, Bo-Eun Kwon, Geun-Shik Lee, Sung-Il Yoon, Seung Goo Kang, Pyeung-Hyeun Kim, Mi-Na Kweon, Hyungjun Yang, Bruce A Vallance and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Jae-Hee AhnLaboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Jaewon ChoLaboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Bo-Eun KwonLaboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University, Chuncheon, 24341, Republic of Korea.ORCID http://orcid.org/0000-0002-8748-1171
Geun-Shik LeeCollege of Veterinary Medicine, Kangwon National University, Chuncheon, 24341, Republic of Korea.ORCID http://orcid.org/0000-0002-3149-8433
Sung-Il YoonDivision of Biomedical Convergence, School of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Seung Goo KangDivision of Biomedical Convergence, School of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Pyeung-Hyeun KimDepartment of Molecular Bioscience, School of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Mi-Na KweonMucosal Immunology Laboratory, Department of Convergence Medicine, University of Ulsan College of Medicine/Asan Medical Center, Seoul, Republic of Korea.
Hyungjun YangDepartment of Pediatrics, British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0002-3213-7568
Bruce A VallanceDepartment of Pediatrics, British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Young-In KimLaboratory of Microbiology, College of Pharmacy, Ajou University, Suwon, 16499, Republic of Korea.
Sun-Young ChangLaboratory of Microbiology, College of Pharmacy, Ajou University, Suwon, 16499, Republic of Korea. sychang@ajou.ac.kr.ORCID http://orcid.org/0000-0001-7336-9245
Hyun-Jeong KoLaboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University, Chuncheon, 24341, Republic of Korea. hjko@kangwon.ac.kr.
Kangwon National University · KRAjou University · KRUniversity of British Columbia · CAUlsan College · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inhibitor of kappa B (IκB)-ζ transcription is rapidly induced by stimulation with TLR ligands and IL-1. Despite high IκBζ expression in inflammation sites, the association of IκBζ with host defence via systemic immune responses against bacterial infection remains unclear. Oral immunisation with a recombinant attenuated Salmonella vaccine (RASV) strain did not protect IκBζ-deficient mice against a lethal Salmonella challenge. IκBζ-deficient mice failed to produce Salmonella LPS-specific IgG, especially IgG2a, although inflammatory cytokine production and immune cell infiltration into the liver increased after oral RASV administration. Moreover, IκBζ-deficient mice exhibited enhanced splenic germinal centre reactions followed by increased total IgG production, despite IκBζ-deficient B cells having an intrinsic antibody class switching defect. IκBζ-deficient CD4

Indexed as

Cell DifferentiationImmunityAdaptor Proteins, Signal TransducingAdministration, OralAnimalsChronic DiseaseGerminal CenterImmunizationImmunoglobulin GInflammationInterferon-gammaLipopolysaccharidesMice, Inbred C57BLSalmonella InfectionsSalmonella typhimuriumSalmonella VaccinesAdaptor Proteins, Signal TransducingImmunoglobulin GInterferon-gammaLipopolysaccharidesNfkbiz protein, mouseSalmonella VaccinesVaccines, Attenuated

Identifiers

PMID31182790
PMCPMC6557891
OpenAlexW2953087963

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.