Evidence map›Paper›PMID 31182770›Full record

ArticleScientific reports2019

Enhanced avidity from a multivalent fluorescent antimicrobial peptide enables pathogen detection in a human lung model.

Ahsan R Akram, Nicolaos Avlonitis, Emma Scholefield, Marc Vendrell, Neil McDonald, Tashfeen Aslam, Thomas H Craven, Calum Gray, David S Collie, Andrew J Fisher and 5 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The role of confocal laser endomicroscopy in pulmonary medicine.European respiratory review : an official journal of the European Respiratory Society · 2023
    Review
  6. Review
  7. Article
  8. Review
  9. Evaluation of Peptide-Based Probes towardACS infectious diseases · 2020
    Article
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Ahsan R AkramEPSRC IRC PROTEUS Hub, Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom. Ahsan.Akram@ed.ac.uk.ORCID http://orcid.org/0000-0003-4605-1682
Nicolaos AvlonitisEaStCHEM, The University of Edinburgh School of Chemistry, Joseph Black Building, West Mains Road, EH9 3FJ, Edinburgh, United Kingdom.
Emma ScholefieldEPSRC IRC PROTEUS Hub, Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom.
Marc VendrellEPSRC IRC PROTEUS Hub, Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom.
Neil McDonaldEPSRC IRC PROTEUS Hub, Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom.
Tashfeen AslamEaStCHEM, The University of Edinburgh School of Chemistry, Joseph Black Building, West Mains Road, EH9 3FJ, Edinburgh, United Kingdom.
Thomas H CravenEPSRC IRC PROTEUS Hub, Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom.
Calum GrayClinical Research Imaging Centre, Queen's Medical Research Institute, Edinburgh BioQuarter, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom.ORCID http://orcid.org/0000-0002-2816-4707
David S CollieThe Roslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, United Kingdom.
Andrew J FisherInstitute of Transplantation, Newcastle University, Freeman Hospital, High Heaton, Newcastle upon Tyne, NE7 7DN, United Kingdom.ORCID http://orcid.org/0000-0003-4822-7223
Paul A CorrisInstitute of Transplantation, Newcastle University, Freeman Hospital, High Heaton, Newcastle upon Tyne, NE7 7DN, United Kingdom.
Timothy WalshEPSRC IRC PROTEUS Hub, Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom.
Christopher HaslettEPSRC IRC PROTEUS Hub, Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom.
Mark BradleyEPSRC IRC PROTEUS Hub, Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom. Mark.Bradley@ed.ac.uk.
Kevin DhaliwalEPSRC IRC PROTEUS Hub, Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom. Kev.Dhaliwal@ed.ac.uk.
Engineering and Physical Sciences Research Council · GBFreeman Hospital · GBUniversity of Edinburgh · GBCentre for Inflammation Research · GBRoslin Institute · GBThe Queen's Medical Research Institute · GB

Funding

Department of Health HICF-0510-069Wellcome Trust
6 · The paper itself

Abstract

Rapid in situ detection of pathogens coupled with high resolution imaging in the distal human lung has the potential to provide new insights and diagnostic utility in patients in whom pneumonia is suspected. We have previously described an antimicrobial peptide (AMP) Ubiquicidin (fragment UBI

Indexed as

Models, BiologicalAnimalsAntimicrobial Cationic PeptidesBacteriaCells, CulturedCystic FibrosisDisease Models, AnimalFluorescent DyesFungiHumansHydrophobic and Hydrophilic InteractionsInflammationLungOxadiazolesPneumoniaSheep7-nitrobenz-2-oxa-1,3-diazoleAntimicrobial Cationic PeptidesFluorescent DyesOxadiazoles

Identifiers

PMID31182770
PMCPMC6557859
OpenAlexW2949327116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.