ArticleScientific reports2019
Conjunctival dysbiosis in mucosa-associated lymphoid tissue lymphoma.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Recent advances and clinical relevance of microbiome dynamics in health and disease.Gut microbes · 2026Review
- Profiling of ocular surface microbiome and its ocular types in children and adolescents.Communications medicine · 2026Article
- Overview of Microorganisms: Bacterial Microbiome, Mycobiome, Virome Identified Using Next-Generation Sequencing, and Their Application to Ophthalmic Diseases.Microorganisms · 2025Review
- Subepithelial Lesions of the Ocular Surface: A Review.Current ophthalmology reports · 2025Review
- Sequencing the ocular surface microbiome: a review of methodological practices and considerations.Frontiers in ophthalmology · 2025Review
- PTTM: dissecting the profile of tumor tissue microbiome to reveal microbiota features and associations with host transcriptome.Briefings in bioinformatics · 2024Article
- Ocular microbiota types and longitudinal microbiota alterations in patients with chronic dacryocystitis with and without antibiotic pretreatment.iMetaOmics · 2024Article
- Dissecting causal links between gut microbiota, inflammatory cytokines, and DLBCL: a Mendelian randomization study.Blood advances · 2024Article
- Fungal dysbiosis and decreased tear mucin at the conjunctiva in patients with conjunctival mucosa-associated lymphoid tissue lymphoma.BMJ open ophthalmology · 2023Article
- Conjunctival Lymphoma.Eye (London, England) · 2023Review
- Metagenomic profiling of ocular surface microbiome changes inFrontiers in cellular and infection microbiology · 2022Article
- Comparison of the ocular surface microbiota between thyroid-associated ophthalmopathy patients and healthy subjects.Frontiers in cellular and infection microbiology · 2022Article
- A complete guide to human microbiomes: Body niches, transmission, development, dysbiosis, and restoration.Frontiers in systems biology · 2022Article
- Differences in the eyelid and buccal microbiome of glaucoma patients receiving long-term administration of prostaglandin analog drops.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
- Elevated levels of Merkel cell polyoma virus in the anophthalmic conjunctiva.Scientific reports · 2021Article
- Emerging Roles for the Gut Microbiome in Lymphoid Neoplasms.Clinical Medicine Insights. Oncology · 2021Review
- The Microbiome of the Meibum and Ocular Surface in Healthy Subjects.Investigative ophthalmology & visual science · 2020Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the conjunctival microbiota and the association between the development of conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma and dysbiosis, DNA samples were collected from 25 conjunctival MALT lymphoma patients and 25 healthy controls. To compare the microbiota, samples were collected from the following four body locations: conjunctiva, meibomian gland, periocular skin and hand. Extracted DNA was analyzed by 16S rRNA sequences, and libraries were sequenced on an Illumina MiSeq sequencer. The differences in bacteria were characterized by using principal coordinate analysis of metagenomics data, and the differences in bacterial compositions were evaluated by linear discriminant analysis effect size. The conjunctival microbiota of MALT lymphoma patients was compositionally different from that of healthy controls. For the conjunctival MALT lymphoma patients, alterations in the microbial composition were detected, and a remarkable change was detected at the conjunctiva. Detailed analysis showed that a specific population of the microbiota, the genus Delftia, was significantly more abundant in conjunctival MALT lymphoma patients, and the genera Bacteroides and Clostridium were less abundant in the MALT lymphoma patients. A specific microbiota on the ocular surface in conjunctival MALT lymphoma patients was detected, and dysbiosis may play an important role in the pathophysiology of conjunctival MALT lymphoma.
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