ArticleScientific reports2019
The combined antimicrobial effect of arginine and fluoride toothpaste.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 40 citations in OpenAlex.
- Oral hygiene agents at work: effects onFrontiers in cellular and infection microbiology · 2026Review
- A novel dual-targeting strategy to suppress cariogenic bacteria and biofilms with engineered ARG/FBG bioactive composites.Regenerative biomaterials · 2026Article
- Arginine combination with fluoride and calcium glycerophosphate: effects of concentration and on biofilm fluid.Future microbiology · 2025Article
- Manipulating the diseased oral microbiome: the power of probiotics and prebiotics.Journal of oral microbiology · 2024Review
- Brief Narrative Review on Commercial Dental Sealants-Comparison with Respect to Their Composition and Potential Modifications.Materials (Basel, Switzerland) · 2023Review
- A Combination of Zinc and Arginine Disrupt the Mechanical Integrity of Dental Biofilms.Microbiology spectrum · 2023Article
- Comparative Effects of Kemphor and Chlorhexidine Mouthwashes on Tooth Staining and Gingivitis: A Randomized Controlled Crossover Clinical Trial.Frontiers in dentistry · 2022Article
- Application of Amorphous Calcium Phosphate Agents in the Prevention and Treatment of Enamel Demineralization.Frontiers in bioengineering and biotechnology · 2022Review
- Concentration-Dependent Multi-Potentiality of L-Arginine: Antimicrobial Effect, Hydroxyapatite Stability, and MMPs Inhibition.Molecules (Basel, Switzerland) · 2021Article
- Combined effect of arginine and fluoride on the growth of Lactobacillus rhamnosus GG.Scientific reports · 2021Article
- Arginine InducedFrontiers in cellular and infection microbiology · 2021Article
- In Silico Selection and In Vitro Evaluation of New Molecules That Inhibit the Adhesion ofInternational journal of molecular sciences · 2020Article
- Effect of a novel synbiotic on Streptococcus mutans.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the study was to investigate the antibacterial effect of arginine (Arg) in NaF toothpaste. 24-h mono-/3-species biofilm cultures of S. mutans, S. sanguis and S. gordonii inoculated sHA discs were subjected to treatment with toothpaste supernatants prepared as - [1]:2% Arg -NaF (0.147% F), [2]:4% Arg-NaF (0.144% F), [3]:8% Arg - NaF (0.138% F), [4]:NaF (0.15%) and [5]:deionized water. After 24-h incubation, the mono-species biofilms were subjected to viability assay using WST-8, SEM and confocal imaging (CLSM). The 3-species biofilm were quantified for bacterial composition by PCR analysis, SEM, CLSM, and RNA isolation with reverse-transcription PCR analysis. Increasing arginine concentrations in NaF toothpaste had no effect on microbial viability. The mono-/3-species biofilm imaging depicted that the 2% Arg-NaF and 4% Arg-NaF had a biofilm disrupting effect. The 3-species biofilm bacterial composition indicated that the 2% Arg-NaF group maintained an ecological homeostasis by inhibiting S. mutans growth and enriching the growth of S. sanguis and S. gordonii. The 2% Arg-NaF group significantly downregulated the expression of virulent gtfB gene and upregulated the expression of sagP with relative dominance of arcA. Incorporation of 2% arginine in NaF toothpaste might enrich the alkali-producing bacteria and provide enhanced counter mechanisms against cariogenic pathogen when compared to NaF toothpaste.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.