Evidence map›Paper›PMID 31182654›Full record

ArticleThorax2019

PGC1α repression in IPF fibroblasts drives a pathologic metabolic, secretory and fibrogenic state.

Nunzia Caporarello, Jeffrey A Meridew, Dakota L Jones, Qi Tan, Andrew J Haak, Kyoung M Choi, Logan J Manlove, Y S Prakash, Daniel J Tschumperlin, Giovanni Ligresti

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thorax, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 93 citations in OpenAlex.

  1. RUNX1 is a mediator of fibrotic activation and epigenetic memory in lung fibroblasts.American journal of respiratory cell and molecular biology · 2026
    Article
  2. Article
  3. Article
  4. Mechanobiology and Resolution of Lung Fibrosis.Annual review of physiology · 2026
    Review
  5. Loss of lung mesenchymal identities in culture and a screening approach to identify restorative cues.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  6. Altered Metabolism in Idiopathic Pulmonary Fibrosis.Journal of cellular physiology · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Current issues in molecular biology · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Aging Delays Lung Repair: Insights from Omics Analysis in Mice with Pulmonary Fibrosis.American journal of respiratory cell and molecular biology · 2023
    Article
  20. Review

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Nunzia CaporarelloPhysiology & Biomedical Engineering, Mayo Clinic Minnesota, Rochester, Minnesota, USA.
Jeffrey A MeridewPhysiology & Biomedical Engineering, Mayo Clinic Minnesota, Rochester, Minnesota, USA.
Dakota L JonesPhysiology & Biomedical Engineering, Mayo Clinic Minnesota, Rochester, Minnesota, USA.
Qi TanPhysiology & Biomedical Engineering, Mayo Clinic Minnesota, Rochester, Minnesota, USA.
Andrew J HaakPhysiology & Biomedical Engineering, Mayo Clinic Minnesota, Rochester, Minnesota, USA.
Kyoung M ChoiPhysiology & Biomedical Engineering, Mayo Clinic Minnesota, Rochester, Minnesota, USA.
Logan J ManloveAnesthesiology and Perioperative Medicine, Mayo Clinic Minnesota, Rochester, Minnesota, USA.
Y S PrakashPhysiology & Biomedical Engineering, Mayo Clinic Minnesota, Rochester, Minnesota, USA.
Daniel J TschumperlinPhysiology & Biomedical Engineering, Mayo Clinic Minnesota, Rochester, Minnesota, USA.
Giovanni LigrestiPhysiology & Biomedical Engineering, Mayo Clinic Minnesota, Rochester, Minnesota, USA ligresti@bu.edu.
Mayo Clinic · USMayo Clinic in Florida · US

Funding

Mechanobiology of Lung FibrosisR01HL092961 · NHLBI · MAYO CLINIC ROCHESTER · PI Daniel J. Tschumperlin · 2009 to 2026
$8.0M
Interdisciplinary Training in Lung Physiology and Biomedical EngineeringT32HL105355 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S., SIECK, GARY C. · 2012 to 2021
$3.9M
Epigenetic regulation of pulmonary fibrosisR01HL142596 · NHLBI · MAYO CLINIC ROCHESTER · PI Giovanni Ligresti · 2018 to 2026
$2.9M
Targeting matrix stiffness in lung and liver fibrosisR01HL133320 · NHLBI · MAYO CLINIC ROCHESTER · PI SHAH, VIJAY H., TSCHUMPERLIN, DANIEL J. · 2016 to 2019
$2.2M
NHLBI NIH HHS R01 HL092961NHLBI NIH HHS R01 HL133320NHLBI NIH HHS R01 HL142596NHLBI NIH HHS T32 HL105355
6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis (IPF) is a fatal ageing-related disease linked to mitochondrial dysfunction. The present study aimed to determine whether peroxisome proliferator activated receptor gamma co-activator 1-alpha (

Indexed as

ActinsAnimalsbeta-GalactosidaseBleomycinCell LineCellular SenescenceCollagen Type ICollagen Type I, alpha 1 ChainCyclin-Dependent Kinase Inhibitor p16FibroblastsFibronectinsGene ExpressionGene Knockdown TechniquesHumansHypoglycemic AgentsIdiopathic Pulmonary FibrosisACTA2 protein, humanActinsbeta-GalactosidaseBleomycinCDKN2A protein, humanCollagen Type ICollagen Type I, alpha 1 ChainCyclin-Dependent Kinase Inhibitor p16FibronectinsFN1 protein, humanGLB1 protein, humanHypoglycemic AgentsNADPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPPARGC1A protein, humanPpargc1a protein, mouseRNA, Small InterferingRosiglitazoneTriiodothyronineidiopathic pulmonary fibrosisinterstitial fibrosis

Identifiers

PMID31182654
PMCPMC6703129
OpenAlexW2951991612

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.