ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Intracortical Dynamics Underlying Repetitive Stimulation Predicts Changes in Network Connectivity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Methodologies to detect cortico-cortical evoked potentials: a systematic review.Frontiers in human neuroscience · 2025Pooled it
- Network reorganization of anterograde thalamic connectivity during non-periodic patterned deep brain stimulation.iScience · 2026Article
- Transcranial magnetic stimulation to the dorsolateral prefrontal cortex modulates single-neuron activity in humans.bioRxiv : the preprint server for biology · 2026Article
- Noninvasive profiling of input-output excitability curves in human prefrontal cortex.bioRxiv : the preprint server for biology · 2025Article
- EEG Biomarkers for a Precision-Medicine Approach to Noninvasive Brain Stimulation for Major Depressive Disorder.Research square · 2025Article
- Article
- Can electrical stimulation replace spontaneous seizures in epilepsy surgery?medRxiv : the preprint server for health sciences · 2025Article
- Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala.bioRxiv : the preprint server for biology · 2025Article
- Macroscale Traveling Waves Evoked by Single-Pulse Stimulation of the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Recent Progress in Flexible Microelectrode Arrays for Combined Electrophysiological and Electrochemical Sensing.Biosensors · 2025Review
- Theta-burst direct electrical stimulation remodels human brain networks.Nature communications · 2024Article
- Mapping cortical excitability in the human dorsolateral prefrontal cortex.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- Real-time optimization to enhance noninvasive cortical excitability assessment in the human dorsolateral prefrontal cortex.bioRxiv : the preprint server for biology · 2024Article
- Effects of transcranial magnetic stimulation on the human brain recorded with intracranial electrocorticography.Molecular psychiatry · 2024Article
- Reliability of the TMS-evoked potential in dorsolateral prefrontal cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Closed-loop neurostimulation for the treatment of psychiatric disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- TMS provokes target-dependent intracranial rhythms across human cortical and subcortical sites.bioRxiv : the preprint server for biology · 2023Article
- Reliability and Validity of Transcranial Magnetic Stimulation-Electroencephalography Biomarkers.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Review
- Spectro-spatial features in distributed human intracranial activity proactively encode peripheral metabolic activity.Nature communications · 2023Article
- Experimental suppression of transcranial magnetic stimulation-electroencephalography sensory potentials.Human brain mapping · 2022Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Targeted stimulation can be used to modulate the activity of brain networks. Previously we demonstrated that direct electrical stimulation produces predictable poststimulation changes in brain excitability. However, understanding the neural dynamics during stimulation and its relationship to poststimulation effects is limited but critical for treatment optimization. Here, we applied 10 Hz direct electrical stimulation across several cortical regions in 14 human subjects (6 males) implanted with intracranial electrodes for seizure monitoring. The stimulation train was characterized by a consistent increase in high gamma (70-170 Hz) power. Immediately post-train, low-frequency (1-8 Hz) power increased, resulting in an evoked response that was highly correlated with the neural response during stimulation. Using two measures of network connectivity, corticocortical evoked potentials (indexing effective connectivity), and theta coherence (indexing functional connectivity), we found a stronger response to stimulation in regions that were highly connected to the stimulation site. In these regions, repeated cycles of stimulation trains and rest progressively altered the stimulation response. Finally, after just 2 min (∼10%) of repetitive stimulation, we were able to predict poststimulation connectivity changes with high discriminability. Together, this work reveals a relationship between stimulation dynamics and poststimulation connectivity changes in humans. Thus, measuring neural activity during stimulation can inform future plasticity-inducing protocols.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.