Evidence map›Paper›PMID 31182632›Full record

ArticleBiology open2019

Effectors of the spindle assembly checkpoint are confined within the nucleus of Saccharomyces cerevisiae.

Lydia R Heasley, Jennifer G DeLuca, Steven M Markus

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lydia R HeasleyDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA lydia.heasley@colostate.edu jennifer.deluca@colostate.edu steven.markus@colostate.edu.ORCID http://orcid.org/0000-0002-8973-1496
Jennifer G DeLucaDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado 80523, USA lydia.heasley@colostate.edu jennifer.deluca@colostate.edu steven.markus@colostate.edu.ORCID http://orcid.org/0000-0002-3598-1721
Steven M MarkusDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado 80523, USA lydia.heasley@colostate.edu jennifer.deluca@colostate.edu steven.markus@colostate.edu.
Colorado State University · US

Funding

Kinetochore Function in Vertebrate CellsR01GM088371 · NIGMS · COLORADO STATE UNIVERSITY · PI DELUCA, JENNIFER G · 2010 to 2018
$3.1M
Regulation of Spindle PositioningR01GM118492 · NIGMS · COLORADO STATE UNIVERSITY · PI MARKUS, STEVEN M · 2016 to 2020
$1.7M
Using the Scientific CV to Study the Effects of Interventions on Research CareersR01GM088731 · NIGMS · UNIVERSITY OF GEORGIA · PI GAUGHAN, MONICA · 2010 to 2013
$737k
NIGMS NIH HHS R01 GM088371NIGMS NIH HHS R01 GM088731NIGMS NIH HHS R01 GM118492
6 · The paper itself

Abstract

The spindle assembly checkpoint (SAC) prevents erroneous chromosome segregation by delaying mitotic progression when chromosomes are incorrectly attached to the mitotic spindle. This delay is mediated by mitotic checkpoint complexes (MCCs), which assemble at unattached kinetochores and repress the activity of the anaphase promoting complex/cyclosome (APC/C). The cellular localizations of MCCs are likely critical for proper SAC function, yet remain poorly defined. We recently demonstrated that in mammalian cells, in which the nuclear envelope disassembles during mitosis, MCCs diffuse throughout the spindle region and cytoplasm. Here, we employed an approach using binucleate yeast zygotes to examine the localization dynamics of SAC effectors required for MCC assembly and function in budding yeast, in which the nuclear envelope remains intact throughout mitosis

Indexed as

Budding yeastMitosisMitotic checkpoint complexMitotic exit networkSpindle assembly checkpoint

Identifiers

PMID31182632
PMCPMC6602339
OpenAlexW2953229272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.