Evidence map›Paper›PMID 31182595›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

New neural activity patterns emerge with long-term learning.

Emily R Oby, Matthew D Golub, Jay A Hennig, Alan D Degenhart, Elizabeth C Tyler-Kabara, Byron M Yu, Steven M Chase, Aaron P Batista

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed.

  1. Neural geometry guides learning.Nature neuroscience · 2026
    Article
  2. Article
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  10. Millimeter-scale selective amplification in the developing visual cortex.bioRxiv : the preprint server for biology · 2026
    Article
  11. Article
  12. Integration of learned artificial sensation with vision during freely moving navigation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  13. Review
  14. Article
  15. Article
  16. Motor cortex flexibly deploys a high-dimensional repertoire of subskills.bioRxiv : the preprint server for biology · 2025
    Article
  17. Article
  18. Article
  19. A neural manifold view of the brain.Nature neuroscience · 2025
    Review
  20. Article

46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Emily R ObyDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213.ORCID 0000-0002-3376-0669
Matthew D GolubCenter for the Neural Basis of Cognition, University of Pittsburgh and Carnegie Mellon University, Pittsburgh, PA 15213.
Jay A HennigCenter for the Neural Basis of Cognition, University of Pittsburgh and Carnegie Mellon University, Pittsburgh, PA 15213.
Alan D DegenhartDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213.
Elizabeth C Tyler-KabaraDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213.ORCID 0000-0003-3286-1094
Byron M YuCenter for the Neural Basis of Cognition, University of Pittsburgh and Carnegie Mellon University, Pittsburgh, PA 15213.
Steven M ChaseCenter for the Neural Basis of Cognition, University of Pittsburgh and Carnegie Mellon University, Pittsburgh, PA 15213.ORCID 0000-0003-4450-6313
Aaron P BatistaDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213; aaron.batista@pitt.edu.

Funding

Training in the Neurobiology of Neurological DiseaseT32NS086749 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Omar El Gharbawie, REBECCA P SEAL · 2014 to 2026
$4.8M
Shaping Neural Population Dynamics to Facilitate LearningR01HD071686 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BATISTA, AARON PAUL, CHASE, STEVEN M · 2011 to 2021
$3.7M
Memory Formation in Motor CortexR01NS129584 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Aaron Paul Batista, Steven M Chase · 2022 to 2026
$2.8M
Training in the Neurobiology of Neurodegenerative DiseaseT32NS007391 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZIGMOND, MICHAEL J · 1997 to 2013
$2.3M
Interrogating and Perturbing Neural DynamicsR01NS105318 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Aaron Paul Batista, Steven M Chase · 2017 to 2026
$2.3M
Multisensory Integration in Action: a Multineuronal and Feedback-Control ApproachR01HD090125 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BATISTA, AARON PAUL, LOUGHLIN, PATRICK J · 2017 to 2021
$1.7M
NICHD NIH HHS R01 HD071686NICHD NIH HHS R01 HD090125NINDS NIH HHS R01 NS105318NINDS NIH HHS R01 NS129584NINDS NIH HHS T32 NS007391NINDS NIH HHS T32 NS086749
6 · The paper itself

Abstract

Learning has been associated with changes in the brain at every level of organization. However, it remains difficult to establish a causal link between specific changes in the brain and new behavioral abilities. We establish that new neural activity patterns emerge with learning. We demonstrate that these new neural activity patterns cause the new behavior. Thus, the formation of new patterns of neural population activity can underlie the learning of new skills.

Indexed as

AnimalsBrain-Computer InterfacesHaplorhiniLearningMemory, Long-TermMotor CortexMotor SkillsNerve NetNeuronsbrain–computer interfacemotor cortexneural populationskill learning

Identifiers

PMID31182595
PMCPMC6660765

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.