ArticleProceedings of the National Academy of Sciences of the United States of America2019
Elevated dopamine signaling from ventral tegmental area to prefrontal cortical parvalbumin neurons drives conditioned inhibition.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- VTA-forebrain connectivity moderates adaptive behavior.Brain structure & function · 2026Review
- Corticonigral projections recruit substantia nigra pars lateralis dopaminergic neurons for auditory threat memories.Nature communications · 2025Article
- Distinct subpopulations of parvalbumin neurons participating in divergent prefrontal functions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- The locus coeruleus influences behavior by coordinating effective integration of fear memories and sensory input.PLoS biology · 2025Article
- Population imaging of internal state circuits relevant to psychiatric disease: a review.Neurophotonics · 2025Review
- Corticonigral projections recruit substantia nigra pars lateralis dopaminergic neurons for auditory threat memories.bioRxiv : the preprint server for biology · 2024Article
- Translational approaches to the neurobiological study of conditional discrimination and inhibition: Implications for psychiatric disease.Behavioral neuroscience · 2024Review
- Modulation of learning safety signals by acute stress: paraventricular thalamus and prefrontal inhibition.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Gains and Losses: Resilience to Social Defeat Stress in Adolescent Female Mice.Biological psychiatry · 2024Article
- Bmal1 haploinsufficiency impairs fear memory and modulates neuroinflammation via the 5-HT2C receptor.Frontiers in pharmacology · 2024Article
- Prefrontal Dopamine in Flexible Adaptation to Environmental Changes: A Game for Two Players.Biomedicines · 2023Review
- Amphetamine disrupts dopamine axon growth in adolescence by a sex-specific mechanism in mice.Nature communications · 2023Article
- Paraventricular Thalamus Dynamically Modulates Aversive Memory via Tuning Prefrontal Inhibitory Circuitry.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Dopaminergic Modulation of Prefrontal Cortex Inhibition.Biomedicines · 2023Review
- Comorbidity of Post-Traumatic Stress Disorder and Alcohol Use Disorder: Animal Models and Associated Neurocircuitry.International journal of molecular sciences · 2022Review
- Cortico-Striatal Activity Characterizes Human Safety Learning via Pavlovian Conditioned Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Effect of Glucocorticoid and 11β-Hydroxysteroid-Dehydrogenase Type 1 (11β-HSD1) in Neurological and Psychiatric Disorders.The international journal of neuropsychopharmacology · 2022Article
- Plexin-A1 expression in the inhibitory neurons of infralimbic cortex regulates the specificity of fear memory in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Elevated activity in the dorsal dentate gyrus reduces expression of fear memory after fear extinction training.Journal of psychiatry & neuroscience : JPN · 2021Article
- Mechanical tibial loading remotely suppresses brain tumors by dopamine-mediated downregulation of CCN4.Bone research · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
Conditioned inhibition is an important process to suppress learned responses for optimal adaptation, but its underlying biological mechanism is poorly understood. Here we used safety learning (SL)/fear discrimination after fear conditioning as a conditioned inhibition model because it demonstrates the essential properties of summation and retardation. Activity of the dorsomedial prefrontal cortex (dmPFC) parvalbumin (PV) neurons bidirectionally regulates spiking levels of dmPFC excitatory neurons and fear states. Responses to safety cues are increased in dopaminergic (DA) neurons in the ventral tegmental area (VTA) and in PV neurons in dmPFC after SL. Plasticity in the VTA is implicated, since SL requires activation of
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.