ArticleProceedings of the National Academy of Sciences of the United States of America2019
Scotopic rod vision in tetrapods arose from multiple early adaptive shifts in the rate of retinal release.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed.
- Evolutionary Shifts in Rhodopsin Function Illuminate Dim-Light Adaptations in Birds.Integrative zoology · 2026Article
- A Pentaradial and Bilateral Combined Photoreception System in the Sea Cucumber is Mediated by a Blue Light-Sensitive R-Opsin.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Visual pigments of basal lineages of bony fishes support independent ecological shifts from a shallow marine to a freshwater niche.Evolution letters · 2026Article
- Comparative phenotypic analysis of rhodopsin supports stepwise evolution of dim-light vision in early vertebrates.Molecular biology and evolution · 2026Article
- Rhodopsin molecular evolution from mouse to human phenylalanine 88 to leucine substitution enhances thermal stability and post-activation decay.Scientific reports · 2026Article
- Structure of human green cone opsin yields insights into mechanisms underlying the rapid decay of its active, signaling state.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Insights into rhodopsin molecular evolution from mice with "humanized" Phe-88 to Leu substitution.Research square · 2025Article
- Genomic and phenotypic evidence support visual and olfactory shifts in primate evolution.Nature ecology & evolution · 2025Article
- Widespread and Convergent Evolution of Cone Monochromacy in Galeomorph Sharks.Molecular biology and evolution · 2025Article
- Parallel Spectral Tuning of a Cone Visual Pigment Provides Evidence for Ancient Deep-Sea Adaptations in Cetaceans.Genome biology and evolution · 2024Article
- Convergent evolutionary shifts in rhodopsin retinal release explain shared opsin repertoires in monotremes and crocodilians.Proceedings. Biological sciences · 2023Article
- Diversified Mammalian Visuasl Adaptations to Bright- or Dim-Light Environments.Molecular biology and evolution · 2023Article
- Placing human gene families into their evolutionary context.Human genomics · 2022Review
- Ancient whale rhodopsin reconstructs dim-light vision over a major evolutionary transition: Implications for ancestral diving behavior.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The Birth of the Mammalian Sleep.Biology · 2022Review
- Rhodopsins: An Excitingly Versatile Protein Species for Research, Development and Creative Engineering.Frontiers in chemistry · 2022Review
- Convergent Phenotypic Evolution of Rhodopsin for Dim-Light Sensing across Deep-Diving Vertebrates.Molecular biology and evolution · 2021Article
- Recreated Ancestral Opsin Associated with Marine to Freshwater Croaker Invasion Reveals Kinetic and Spectral Adaptation.Molecular biology and evolution · 2021Article
- Convergent spectral shifts to blue-green vision in mammals extends the known sensitivity of vertebrate M/LWS pigments.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Emerging Frontiers in the Study of Molecular Evolution.Journal of molecular evolution · 2020Article
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7 authors.
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Abstract
The ability of vertebrates to occupy diverse niches has been linked to the spectral properties of rhodopsin, conferring rod-based vision in low-light conditions. More recent insights have come from nonspectral kinetics, including the retinal release rate of the active state of rhodopsin, a key aspect of scotopic vision that shows strong associations with light environments in diverse taxa. We examined the retinal release rates in resurrected proteins across early vertebrates and show that the earliest forms were characterized by much faster rates of retinal release than more recent ancestors. We also show that scotopic vision at the origin of tetrapods is a derived state that arose via at least 4 major shifts in retinal release rate. Our results suggest that early rhodopsin had a function intermediate to that of modern rod and cone pigments and that its well-developed adaptation to low light is a relatively recent innovation since the origin of tetrapods.
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