Evidence map›Paper›PMID 31182571›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Matthew T Henke, Douglas J Kenny, Chelsi D Cassilly, Hera Vlamakis, Ramnik J Xavier, Jon Clardy

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 500 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
500citing papers in PubMed, 5 pooled it
28.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

500 citing papers in PubMed, 5 syntheses or guidelines pooled it, 794 citations in OpenAlex.

  1. Pooled it
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  13. Observational
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440 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Matthew T HenkeDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston MA 02115.ORCID 0000-0001-8325-6420
Douglas J KennyBroad Institute of MIT and Harvard, Cambridge, MA 02142.
Chelsi D CassillyDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston MA 02115.
Hera VlamakisBroad Institute of MIT and Harvard, Cambridge, MA 02142.
Ramnik J XavierBroad Institute of MIT and Harvard, Cambridge, MA 02142.
Jon ClardyDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston MA 02115; jon_clardy@hms.harvard.edu.ORCID 0000-0003-0213-8356
Broad Institute · USHarvard University · US

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 1991 to 2026
$35.3M
Identification and characterization of gut microbial bioactive molecules that determine predisposition to autoimmune disease and atopyR01AT009708 · NCCIH · HARVARD MEDICAL SCHOOL · PI CLARDY, JON, XAVIER, RAMNIK J · 2017 to 2021
$3.3M
Elucidating the role of an immunomodulator from a gut microbe in inflammatory bowel diseaseF32GM126650 · NIGMS · HARVARD MEDICAL SCHOOL · PI HENKE, MATTHEW THOMAS · 2017 to 2020
$186k
NCCIH NIH HHS R01 AT009708NIDDK NIH HHS P30 DK043351NIGMS NIH HHS F32 GM126650
6 · The paper itself

Abstract

A substantial and increasing number of human diseases are associated with changes in the gut microbiota, and discovering the molecules and mechanisms underlying these associations represents a major research goal. Multiple studies associate

Indexed as

AnimalsCells, CulturedCrohn DiseaseEubacterialesGastrointestinal MicrobiomeMiceMice, Inbred C57BLPolysaccharides, BacterialTumor Necrosis Factor-alphaPolysaccharides, BacterialTumor Necrosis Factor-alphainflammatory bowel diseasemicrobiomepolysaccharide

Identifiers

PMID31182571
PMCPMC6601261
OpenAlexW2951518977

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.